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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제6호
- 발행연도
- 2008.1
- 수록면
- 1,179 - 1,185 (7page)
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The immune-stimulating activities of Bordetella bronchiseptica antigens containing dermonecrotoxin (BBD) loaded in chitosan microspheres (CMs) have already been reported in vitro and in vivo with a mouse alveolar macrophage cell line (RAW264.7) and mice. Therefore, this study attempted to demonstrate the successful induction of mucosal immune responses after the intranasal administration of BBD loaded in CMs (BBD-CMs) in colostrum-deprived pigs. The BBD was introduced to the CMs using an ionic gelation process involving tripolyphosphate (TPP). Colostrum-deprived pigs were then directly immunized through intranasal administration of the BBD-CMs. A challenge with a field isolate of B. bronchiseptica was performed ten days following the final immunization. The BBD-specific IgG and IgA titers, evident in the nasal wash and serum from the vaccinated pigs, increased with time (p<0.05). Following the challenge, the clinical signs of infection were about 6-fold lower in the vaccinated pigs compared with the nonvaccinated pigs. The grades for gross morphological changes in the turbinate bones from the vaccinated pigs were also significantly lower than the grades recorded for the nonvaccinated pigs (p<0.001). Therefore, the mucosal and systemic immune responses induced in the current study would seem to indicate that the intranasal administration of BBD-CMs may be an effective vaccine against atrophic rhinitis in pigs.
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참고문헌 (23)
참고문헌 신청
[학술지(정
Aksungur, P. / 2004 / Chitosan delivery systems for the treatment of oral mucositis: In vitro and in vivo studies. J. Control / Release 98 : 269 ~ 279
Bokor-Bratic, M. / 2000 / Clinical significance of analysis of immunoglobulin A levels in saliva. Med / Pregl 53 : 164 ~ 168
Challacombe, S. J. / 1995 / Assessing mucosal humoral immunity. Clin. Exp / Immunol 100 : 181 ~ 182
Chanter, N. / 1989 / Interactions between Bordetella bronchiseptica and toxigenic Pasteurella multocida in atrophic rhinitis of pigs. Res. Vet / Sci 47 : 48 ~ 53
Aksungur, P. / 2004 / Chitosan delivery systems for the treatment of oral mucositis: In vitro and in vivo studies. J. Control / Release 98 : 269 ~ 279
Bokor-Bratic, M. / 2000 / Clinical significance of analysis of immunoglobulin A levels in saliva. Med / Pregl 53 : 164 ~ 168
Challacombe, S. J. / 1995 / Assessing mucosal humoral immunity. Clin. Exp / Immunol 100 : 181 ~ 182
Chanter, N. / 1989 / Interactions between Bordetella bronchiseptica and toxigenic Pasteurella multocida in atrophic rhinitis of pigs. Res. Vet / Sci 47 : 48 ~ 53
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