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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2001.12
- 수록면
- 241 - 248 (8page)
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초록· 키워드
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Exposure to 2-Bromopropane has been known to cause degeneration of male germ cells. However, the mechanism underlying this process is poorly understood. The objective of this study was to determine whether or not the exposure of male Sprague-Dawley rats to 2-BP induces apoptosis in male germ cells. Male rats (N=3 or 4 in each group) were orally administered either with the corn oil vehicle (10ml/kg body weight) or with 2-BP (3,500mg/kg) once a day for 3 days. The presence of apoptosis was determined by TUNEL detection in situ and by an increase in DNA fragmentation. A low spontaneous incidence of apoptosis was observed in vehicle control animals, especially in pre-meiotic germ cells of stages Ⅰ-Ⅵ and stages ⅩⅡ-ⅩⅣ of the seminiferous tubules. In 2-BP exposure rats, the incidence of apoptosis markedly increased at 4h, reached a peak at 8h(about 7-fold over control), and then decreased rapidly to control levels by 48h after the last administration. Although apoptosis induced by 2-BP occurred in all stages of germ cells, it was most pronounced in spermatogonia and early spermatocytes in stages Ⅰ-Ⅵ and stages ⅩⅡ-ⅩⅣ. Taken together, our results suggest that apoptosis is involved in the toxicity of testicular germ cells resulting in oligospermia or azoospermia after exposure to 2-BP.
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UCI(KEPA) : I410-ECN-0101-2009-513-013456090