지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제38권 제4호
- 발행연도
- 2004.1
- 수록면
- 228 - 237 (10page)
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초록· 키워드
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Background : Spermatogenesis is regulated by various cellular reactions, and especially
cell proliferation and apoptosis. Methods : We investigated the morphological changes and
the apoptotic molecular changes in mouse testis induced by the endocrine disrupting chemicals.
ICR mice were treated with bisphenol A (BPA), 2-bromopropane (2-BP) and diethylstilbesterol
(DES). Histological examination and immunohistochemical staining, TUNNEL staining
and RNAse protection assay were conducted. Results : Testes treated with BPA showed
normal spermatogenesis and the proliferation activity, and the density of the cells was similar
with those in the control. 2-BP and DES groups, which showed a decrease of germ cells near
the basal layer and degenerative changes. The proliferative activity identified by PCNA staining
was significantly decreased in the 2-BP and DES groups (p<0.05). The apoptosis was significantly
increased in the 2-BP group however, a significant decrease was noted in the BPA
group (p<0.05). Among apoptosis-related molecules, the expression of Fas, Fas ligand, TRAIL,
TNFp55 and caspase 1, 3, 6 and 8 were changed according to the change of the degree of
apoptosis in all groups. Conclusions : Endocrine disrupting chemicals induced cellular injury
in mouse testis through the changes of proliferative activity and apoptosis which was regulated
by a number of apoptosis-related molecules. This probably results in the abnormality of spermatogenesis
in mouse testis.
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참고문헌 (20)
참고문헌 신청
/ 1996 / Targeted disruption of theestrogen receptor gene in male mice causes alteration of spermato-genesis and infertility. 137 : 4796 ~ 4805
/ 1997 / A role for estrogens in the malereproductive system. 390 : 509 ~ 512
/ 1998 / Are estrogens carcino-genic during development of the testes? 106 : 240 ~ 242
/ 1998 / Leydig cell apoptosis in the rat testes after administrationof the cytotoxin ethane dimethanesulphonate role of the Bcl-2 familymembers 157 : 317 ~ 326
/ 1999 / Effects of 2-bromopropaneon spermatogenesis in the Sprague-Dawley rat 13 : 179 ~ 187
/ 1997 / A role for estrogens in the malereproductive system. 390 : 509 ~ 512
/ 1998 / Are estrogens carcino-genic during development of the testes? 106 : 240 ~ 242
/ 1998 / Leydig cell apoptosis in the rat testes after administrationof the cytotoxin ethane dimethanesulphonate role of the Bcl-2 familymembers 157 : 317 ~ 326
/ 1999 / Effects of 2-bromopropaneon spermatogenesis in the Sprague-Dawley rat 13 : 179 ~ 187
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