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자료유형
학술저널
저자정보
저널정보
한국독성학회 Toxicological Research Journal of Toxicology and Public Health Vol.17 No.4
발행연도
2001.12
수록면
287 - 296 (10page)

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초록· 키워드

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The acute oral LD50 toxicity values of isazofos, pyraclofos, diazinon and methomyl were determined for Japanese quail based on OECD guideline. The LD_(50) of isazofos, pyraclofos and diazinon was 16.26 mg/kg, 41.26 mg/kg and 7.11 mg/kg body weight in female respectively. And the LD_(50) of each chemicals in male was 21.44, 35.64, 8.28 mg/kg body weight respectively. Diazinon was the most susceptible compounds to Japanese quail in both sexes. The LD_(50) of methomyl was 21.24 mg/kg body weights in female, and 28.28 mg/kg body weight in male respectively. Diazinon, isazofos and methomyl were more toxic in the female than male. The symptoms of poisoning were similar in quails administrated with each chemicals. The clinical signs in Japanese quail were ataxia, salivation, diarrhea, ruffled feather and convulsion at dead point. There were severe hemorrhage and catarrhal inflammation from duodenum to ileum in all compounds. In Japanese quail treated with organophosphorus and carbamate compounds, brain acetylcholinesterase was inhibited by 88-96. The recovery was not observed after 5h in sublethal dose.

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