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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.12
- 수록면
- 401 - 409 (9page)
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Phthalate esters have possible effects on the endocrine system. Di-n-butyl phthalate (DBP) is one of the most commonly used phthalic acid esters (PAEs). It is extensively used as a plasticizer in elastomers, as a solvent for printing inks and resins, and as a textile lubricating agnet. It is also present in the formulations of various cosmetic products. DBP has been identified as a reproductive toxicant in several animal species and also known as a endocrine disruptor. The objective of this study was to investigate the effect of DBP on developmental immune function using rat pups as experimental animals. Timed-bred pregnant SD rats were orally dosed with 0, 250, 500, or 750 mg DBP/kg body weight once a day from gestational day (GD) 5 to 18 and postpartum day (PD) 3 to 18. On PD22, the dams and their pups were euthanized and examined for alteration in parameters associated to immune funcion. The results showed no significant changes in body weight, thymus weight, thymus and spleen cellutarities, the polyclonal activation responses of splenocyte with ConA and LPS, and also the distribution of arterial blood cells and thymocyte subsets in both rat dams and pups. However DBP exposure on rat dams resulted in increases of liver weights of dams and their pups except 750 mg DBP/kg, and body and spleen weights in pups except 750 mg DBP/kg. On the other hands, distribution rates of CD8^+ T cells at 500mg DBP/kg and B cells at 750mg DBP/kg among splenocyte subsets were significantly increased in rat pups, unlike dams. Reasons of these distribution alterations of CD8^+ T cells and B cells in rat pups are under study.
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UCI(KEPA) : I410-ECN-0101-2009-513-013456676