지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 279 - 286 (8page)
이용수
초록· 키워드
오류제보하기
Objectives : Platinum nanoparticles (PNPs) are potentially useful for sensing, catalysis, and other applications in the biological and medical sciences. However, little is known about PNP toxicity. In this study, adverse effects of PNPs on the postnatal development of mouse pubs were investigated.
Methods : PNPs (size: 20 ㎚) were prepared and orally administered to mice during premating, gestation, and lactation periods (0.25 ㎎/㎏, 0.5 ㎎/㎏, and 1 ㎎/㎏). Maternal and pup toxicity were evaluated.
Results : PNPs did not affect blood biochemical parameters or mortality in dams during the experimental period. Histopathological signs were not observed and pup number was not different between the control and treated groups. Deformity and stillbirth were not observed in the pups. However, PNPs increased pup mortality and decreased the infant growth rate during the lactation period.
Conclusion : PNPs may have adverse effects to the postnatal development of mouse pups.
Methods : PNPs (size: 20 ㎚) were prepared and orally administered to mice during premating, gestation, and lactation periods (0.25 ㎎/㎏, 0.5 ㎎/㎏, and 1 ㎎/㎏). Maternal and pup toxicity were evaluated.
Results : PNPs did not affect blood biochemical parameters or mortality in dams during the experimental period. Histopathological signs were not observed and pup number was not different between the control and treated groups. Deformity and stillbirth were not observed in the pups. However, PNPs increased pup mortality and decreased the infant growth rate during the lactation period.
Conclusion : PNPs may have adverse effects to the postnatal development of mouse pups.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
Fang B / 2009 / Homogeneous deposition of platinum nanoparticles on carbon black for proton exchange membrane fuel cell / J Am Chem Soc 131(42):15330~15338
Cheng H / 2009 / Polyethylene glycol-stabilized platinum nanoparticles: the efficient and recyclable catalysts for selective hydrogenation of o-chloronitrobenzene to o-chloroaniline / J Colloid Interface Sci 336(2):675~678
Hamasaki T / 2008 / Kinetic analysis of superoxide anion radical-scavenging and hydroxyl radical-scavenging activities of platinum nanoparticles / Langmuir 24(14):7354~7364
2009 / Platinum nanoparticle antioxidants inhibit pulmonary inflammation in mice exposed to cigarette smoke / Pulm Pharmacol Ther 22(4):340~349
Theron AJ / 2004 / Effects of platinum and palladium ions on the production and reactivity of neutrophil-derived reactive oxygen species / Free Radic Biol Med 36(11):1408~1417
Cheng H / 2009 / Polyethylene glycol-stabilized platinum nanoparticles: the efficient and recyclable catalysts for selective hydrogenation of o-chloronitrobenzene to o-chloroaniline / J Colloid Interface Sci 336(2):675~678
Hamasaki T / 2008 / Kinetic analysis of superoxide anion radical-scavenging and hydroxyl radical-scavenging activities of platinum nanoparticles / Langmuir 24(14):7354~7364
2009 / Platinum nanoparticle antioxidants inhibit pulmonary inflammation in mice exposed to cigarette smoke / Pulm Pharmacol Ther 22(4):340~349
Theron AJ / 2004 / Effects of platinum and palladium ions on the production and reactivity of neutrophil-derived reactive oxygen species / Free Radic Biol Med 36(11):1408~1417
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UCI(KEPA) : I410-ECN-0101-2012-539-003787038