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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Human immune system acts to protect the host from infectious agents (bacteria, viruses, fungi, parasites) and from other noxious insults. However, immune diseases are sometimes caused by the impairment of immune system leading to abnormal immune response. Especially, autoimmune diseases are very diverse and often bring serious damage. Although many active investigations to reveal the etiological mechanisms concerning the autoimmune diseases, it still remains unclear. After proposing a HERV (human endogenous retrovirus) as a candidate autoimmune gene in type I diabetes, it is newly attracting our attention for demonstrating that an endogenous human retroviral superantigen can be transactivated by interferon-α (IFN-α) or Epstein-Barr virus (EBV) infection. These might provide us with powerful clues to carry out further studies to overcome autoimmune diseases as the presentation of a relatively clear connection between endogenous superantigens and human diseases.
목차
Abstract
서 론
자가면역 질환과 HERV
Superantigen으로서의 HERV
HERV의 발현과 환경적 요인
앞으로의 전망
요 약
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UCI(KEPA) : I410-ECN-0101-2009-470-014220454