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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 2 - 16 (15page)
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Current therapies for autoimmune diseases are not
cures but merely palliatives, aimed at reducing
symptoms. For the most part, these treatments
provide nonspecific suppression of the immune
system and thus do not distinguish between a
pathogenic autoimmune response and a protective
immune response. Recently emerging evidence
not only has indicated the involvement of members
of the TNF receptor/ligand superfamilies but
also has revealed exciting innovative strategies for
the treatment of autoimmune diseases and other
chronic inflammatory diseases without depressing
the immune response in general. In this review,
we will discuss the regulatory mechanisms of TNF
receptor/ligand family members, such as HVEM/
LIGHT, 4-1BB/4-1BBL, and GITR/GITRL that regulate
T and B cell functions and participate in the
process of inflammatory diseases. We will also discuss
how intervening in the costimulatory pathways
mediated by these molecules might have
some potential as a therapeutic approach to immune
disorders.
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