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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.9
- 수록면
- 78 - 87 (10page)
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This study was to investigate single and repeated-dose toxicities of DFA IV, a new
candidate of nutraceutical which has preventive effect on anemia and osteoporosis. In single-dose
oral toxicity study, the test article were administered once by gavage to rats at dose level of 0, 2,000
and 5,000 mg/kg. No dead animal, abnormal sign and abnormal necropsy finding was found in control
and treated groups. Thus the approximate lethal dose of DFA IV was considered to be higher
than 5,000 mg/kg in rats. In four week repeated dose oral toxicity study, the test article was administered
once daily by gavage to rats at dose levels of 0, 500, 1,000 and 2,000 mg/kg. No abnormality
was observed in mortality, clinical findings, body weight changes, food and water consumptions,
opthalmoscopic findings, hematological findings, necropsy findings, organ weights and histopathological
findings. In urinalysis, specific gravity was increased in 2,000 mg/kg groups of male rats. In serum
biochemical analysis, creatine phosphokinase was increased in all treatment groups of male rats.
These increases in urine specific gravity and serum creatine phosphokinase activity were not accompanied
with related signs such as histopathological changes or clinical findings. In conclusion, four
week repeated oral dose of DFA IV to rats did not cause apparent toxicological change at the dose of
500, 1,000 or 2000 mg/kg body weight. Thus it is suggested that no-observed-adverse-effect level
(NOAEL) of DFA IV in rats would be 2,000 mg/kg/day body weight.
candidate of nutraceutical which has preventive effect on anemia and osteoporosis. In single-dose
oral toxicity study, the test article were administered once by gavage to rats at dose level of 0, 2,000
and 5,000 mg/kg. No dead animal, abnormal sign and abnormal necropsy finding was found in control
and treated groups. Thus the approximate lethal dose of DFA IV was considered to be higher
than 5,000 mg/kg in rats. In four week repeated dose oral toxicity study, the test article was administered
once daily by gavage to rats at dose levels of 0, 500, 1,000 and 2,000 mg/kg. No abnormality
was observed in mortality, clinical findings, body weight changes, food and water consumptions,
opthalmoscopic findings, hematological findings, necropsy findings, organ weights and histopathological
findings. In urinalysis, specific gravity was increased in 2,000 mg/kg groups of male rats. In serum
biochemical analysis, creatine phosphokinase was increased in all treatment groups of male rats.
These increases in urine specific gravity and serum creatine phosphokinase activity were not accompanied
with related signs such as histopathological changes or clinical findings. In conclusion, four
week repeated oral dose of DFA IV to rats did not cause apparent toxicological change at the dose of
500, 1,000 or 2000 mg/kg body weight. Thus it is suggested that no-observed-adverse-effect level
(NOAEL) of DFA IV in rats would be 2,000 mg/kg/day body weight.
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