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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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MCM proteins are essential for eukaryotic DNA replication, playing roles in the initiation and elongation of DNA replication. MCM proteins expression is much higher in malignant tissues than normal tissues. Several reports have indicated the usefulness of MCM proteins as markers of cancer cells in histopathological diagnosis. However, the cause of enhanced expression of MCM proteins in cancer cells remain to be clarified. The purpose of this study is to examine the relative transcriptional activities of human mcm gene promoters in cancer and normal cells. The minimal promoter region required for transcription of a luciferase reporter gene was contained an E-box and one E2F site. In addition, luciferase activities from mcm7 and mcm2 promoter/luciferase gene reporter constructs were significantly increased in cancer cells at 8 times compared with normal cells. E-box and E2F binding site in the promoter of mcm genes are responsible for different mechanism of transcription regulation on the cellular environment.
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Abstract
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참고문헌
참고문헌 (31)
참고문헌 신청
[학술지(정기간행물)] - / 2002 / DNA replication in eukaryotic cells 71 : 333 ~ 374
[학술지(정기간행물)] - / 1998 / Gene amplification in human cancers In The Genetic Basis of Human Cancer (Vogelstein, B. & Kinzler, K.W., eds). : 161 ~ 172
[학술지(정기간행물)] - / 1995 / Purification of an MCM-containing complex as a component of the DNA replication licensing system 375 : 418 ~ 421
[학술지(정기간행물)] - / 1988 / Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene : 15335 ~ 15341
[학술지(정기간행물)] - / 1999 / Minichromosome maintenance proteins as biological markers of dysplasia and malignancy 5 : 2121 ~ 2132
[학술지(정기간행물)] - / 1998 / Gene amplification in human cancers In The Genetic Basis of Human Cancer (Vogelstein, B. & Kinzler, K.W., eds). : 161 ~ 172
[학술지(정기간행물)] - / 1995 / Purification of an MCM-containing complex as a component of the DNA replication licensing system 375 : 418 ~ 421
[학술지(정기간행물)] - / 1988 / Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene : 15335 ~ 15341
[학술지(정기간행물)] - / 1999 / Minichromosome maintenance proteins as biological markers of dysplasia and malignancy 5 : 2121 ~ 2132
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UCI(KEPA) : I410-ECN-0101-2009-470-014448696