Significance of Hemodynamic Effects on the Generation of Atherosclerosis

Sang-Ho Suh; Hyung-Woon Roh; Dong-Joo Kim; Hyuck-Moon Kwon; Byoung-Kwon Lee

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자료유형: 학술저널

저자정보: Sang-Ho Suh Hyung-Woon Roh Dong-Joo Kim Hyuck-Moon Kwon Byoung-Kwon Lee

저널정보: 대한기계학회 Journal of Mechanical Science and Technology Journal of Mechanical Science and Technology Vol.19 No.3

발행연도: 2005.3

수록면: 836 - 845 (10page)

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Atherosclerosis, which is a degenerative vascular disease, is believed to occur in the blood vessels due to deposition of cholesterol or low density lipoprotein (LDL) Atherosclerotic lumen narrowing causes reduction of blood flow due to hemodynamic features Several hypothetical theories related to the hemodynamic effects have been reported. high shear stress theory, low shear stress theory, high shear stress gradient theory, flow separation and turbulence theory, and high pressure theory However, no one theory clearly explains the causes of atherosclerosis The objective of the present study was to investigate the mechanism of the generation of atherosclerosis in the study, the database of Korean carotid and coronary arteries for geometrical and hemodynamic clinical data was established The atherosclerotic Sites were predicted by the computer simulations. The results of the computer Simulation were compared with the in vivo experimental results, and then the pathogenesis of atherosclerosis by using the clinical data and several hypothetical theories were investigated From the investigation, it was concluded carefully that the mechanism of the generation of athelosclerosls was related to the hemodynamic effects such as flow separation and oscillatory wall shear stress on the vessel walls.

참고문헌 (9)

참고문헌 신청

Caro, C G, Fitz-Gerald, J M and Schroter, R C, 1971, "Atheroma and Arterial Wall Shear Observation, Correlation and Proposal of a Shear Dependent Mass Transfer Mechanism for Atherogenesis," Proc R. Soc. B, Vol 177, pp 109~159

Cho, M T, Roh, H W, Suh, S H and Kim, J S, 2002, "Pulsatile Flow Analysis of Newtonian Fluid in Circular Tube," KSME (B), Vol 26, No 1, pp 1585~1596

Fox, J A and Hugh, A E, 1966, "Localization of Atheroma a Theory Based on Boundary Layer Separation," Br Heart J, Vol 28, No 3, pp 388~399

Fry, D L, 1972, "Response of the Arterial Wall to Certain Physical Factors Atherogenesis Initialing Factors," A Ciba Foundation Symp, ASP, Amsterdam, The Nethelands, pp 40~83

Lee, B K, Kwon, H M, Hong, B K, Park, B E, Suh, S H, Cho, M T, Lee, C S, Kim, M C, Kim, C J, Yoo, S S and Kim, H S, 2001, "Hemodynamic Effects on Atherosclerosis-Prone Coronary Artery wall Shear Stress/Rate Distribution and Impedance Phase Angle In Corona

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