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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.6
- 수록면
- 70 - 77 (8page)
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초록· 키워드
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Ginseng has an anti-cancer effect in several cancer models. As a mechanism study of ginsenoside-induced growth inhibition in cancer cells, we measured change of membrane potential in prostate cancer and glioma cells by ginsenosides, active constituents of ginseng. Membrane potential was estimated by measuring fluorescence change of DiBAC-loaded cells. Among 11 ginsenosides tested, ginsenosides Rb₂, Rg₃, and Rh₂ increased significantly and robustly the membrane potential in a concentration-dependent manner in prostate cancer and glioma cells. Ginsenosides Rc, Ro, and Rb₁ slightly increased membrane potential. The ginsenoside-induced membrane potential increase was not affected by treatment with pertussis toxin or U73122. The ginsenoside-induced membrane potential increase was not diminished in Na?-free or HCO₃?-free media. Furthermore, the ginsenoside-induced increase of membrane potential was not changed by EIPA (5-(N-ethyl-N-isopropyl)-amiloride), SITS (4-acetoamido-4’-isothiocyanostilbene-2,2’-disulfonic acid), and omeprazole. In summary, ginsenosides Rb₂, Rg₃, and Rh₂ increased membrane potential in prostate cancer and glioma cells in a GPCR-independent and Na? independent manner.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
FOOTNOTE
ACKNOWLEDGEMENT
REFERENCE
참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)] - Rhim, J. S. / 1997 / Human prostate carcinogenesis 8 (4) : 305 ~ 328
[학술지(정기간행물)] - See, W. A / 2003 / Adjuvant hormone therapy after radiation or sur-gery for localized or locally advanced prostate cancer 4 (5) : 351 ~ 362
[학술지(정기간행물)] - Sandler, H. M., / 2003 / Combinedmodality treatment for prostate cancer: role of chemotherapy 30 : 95 ~ 100
[학술지(정기간행물)] - Teicher, B. A., / 1997 / Prostate carcinoma response to cytotoxic therapy: in vivoresistance 11 (6) : 453 ~ 461
[학술지(정기간행물)] - Baumgartner / 1993 / Role of the MDR-1-encoded multiple drug resistance phenotype in prostate can-cer cell lines : 5 1544 ~ 1547
[학술지(정기간행물)] - See, W. A / 2003 / Adjuvant hormone therapy after radiation or sur-gery for localized or locally advanced prostate cancer 4 (5) : 351 ~ 362
[학술지(정기간행물)] - Sandler, H. M., / 2003 / Combinedmodality treatment for prostate cancer: role of chemotherapy 30 : 95 ~ 100
[학술지(정기간행물)] - Teicher, B. A., / 1997 / Prostate carcinoma response to cytotoxic therapy: in vivoresistance 11 (6) : 453 ~ 461
[학술지(정기간행물)] - Baumgartner / 1993 / Role of the MDR-1-encoded multiple drug resistance phenotype in prostate can-cer cell lines : 5 1544 ~ 1547
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UCI(KEPA) : I410-ECN-0101-2009-524-015638137