개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
A tumor suppressor, merlin is a member of ERM family proteins. It consists of N-terminal FERM domain, α-helical region, and C-terminal domain. Alternative splicing of merlin's mRNA generates two isotypes of merlin. Isotype I, which has exon17 at the C-terminus instead of exon16 in isotype II, is known to have tumor suppressor activity. Like other ERM proteins, the C-terminal domain of merlin isotype I interacts to its FERM domain. That of isotype II, however, was reported not to bind FERM domain despite the large common part of C-terminal domain, which possibly binds FERM domain. Here, we show the binding of FERM domain to both C-terminal domains of merlin's two isotypes by isothermal titration calorimetry. These results support that merlin isotype II also can form a closed conformation or a multimer by intramolecular or intermolecular interactions using their FERM domain and C-terminal domain.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Baser, M. E. / 2003 / Neurofibromatosis 2 / Curr. Opin. Neurol 16 : 27 ~ 33
2. [학술지(정기간행물)] - Berryman, M. / 1995 / Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis / J. Cell Biol 131 : 1231 ~ 1242
3. [학술지(정기간행물)] - Bianchi, A. B. / 1994 / Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types / Nat. Genet 6 : 185 ~ 192
4. [학술지(정기간행물)] - Evans, D. G. / 2000 / Neurofibromatosis type 2 / J. Med. Genet 37 : 897 ~ 904
5. [학술지(정기간행물)] - Gary, R. / 1993 / Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins / Proc. Natl. Acad. Sci. USA 90 : 10846 ~ 10850
2. [학술지(정기간행물)] - Berryman, M. / 1995 / Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis / J. Cell Biol 131 : 1231 ~ 1242
3. [학술지(정기간행물)] - Bianchi, A. B. / 1994 / Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types / Nat. Genet 6 : 185 ~ 192
4. [학술지(정기간행물)] - Evans, D. G. / 2000 / Neurofibromatosis type 2 / J. Med. Genet 37 : 897 ~ 904
5. [학술지(정기간행물)] - Gary, R. / 1993 / Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins / Proc. Natl. Acad. Sci. USA 90 : 10846 ~ 10850
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Comparison of Exon-boundary Old and Young Domains during Metazoan Evolution
Genomics & informatics
2009 .01
-
하이브리도마에서 면역글로불린 Isotype의 자생적 변전
The Journal of the Korean Society for Microbiology
1988 .06
-
ON SOME UNBOUNDED DOMAINS FOR A MAXIMUM PRINCIPLE
순수 및 응용수학
2016 .01
-
Functional analysis of N- and C- terminal domains in human tyrosinase
한국분석과학회 학술대회
2012 .05
-
Medium Optimization and Application of Affinity Column Chromatography for Trypsin Production from Recombinant Streptomyces griseus
Journal of Microbiology and Biotechnology
2009 .01
-
Exploring Cross-function Domain Interaction Map
한국생물정보시스템생물학회 학술대회
2005 .01
-
Prediction Accuracy Evaluation of Domain and Domain Combination Based Prediction Methods for Protein-Protein Interaction
Bioinformatics and Biosystems
2006 .01
-
t-SPLITTING SETS S OF AN INTEGRAL DOMAIN D SUCH THAT DS IS A FACTORIAL DOMAIN
한국수학논문집
2013 .01
-
KAPLANSKY-TYPE THEOREMS IN GRADED INTEGRAL DOMAINS
대한수학회보
2015 .01
-
A note on ascend and descend of factorization properties
대한수학회보
2006 .01
-
Study on the Surface Magnetic Domain Structure of Thin - Gauged 3% Si - Fe Strips using Scanning Electron Microscopy with Polarization Analysis
Journal of Magnetics
1998 .06
-
A new characterization of Pr\"ufer $v$-multiplication domains
한국수학논문집
2015 .01
-
A HALF-CENTERED STAR-OPERATION ON AN INTEGRAL DOMAIN
대한수학회지
2017 .01
-
Integral domains with finitely many star operations of finite type
한국수학논문집
2012 .01
-
Semigroup rings as H-domains
한국수학논문집
2011 .01
-
Domain Wall Types and Field-Induced Domain Wall Motions in L-shaped Nanowires
한국자기학회 학술연구발표회 논문개요집
2010 .12
-
Dimerization of terminal protein domain of HBV polymerase
한국동물학회 학술대회
1998 .01
-
Study on Magnetic Domain and Domain Dynamics in Co Thin Films with In - Plane Magnetic Anisotropy
한국자기학회 학술연구발표회 논문개요집
2001 .04
-
Cholera Toxin B Subunit Enhances IgA Isotype Switching in the Presence of Interleukin-2 at the Clonal Level
미생물학회지
1993 .12
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Development of New Vector Systems as Genetic Tools Applicable to Mycobacteria
Ji-A Jeong
,
Ha-Na Lee
,
In-Jeong Ko
외 1명
생명과학회지
2013
.02
Thermodynamics of the binding of Substance P to lipid membranes
Woong Hyoung Lee
,
Chul Kim
분석과학
2017
.04
Relationship of the Redox State of Pyridine Nucleotides and Quinone Pool with Spectral Complex Formation in Rhodobacter sphaeroides 2.4.1
In-Jeong Ko
,
Jeong-Il Oh
생명과학회지
2009
.07
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-470-015921407