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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.9
- 수록면
- 197 - 205 (9page)
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Cancer metastasis is a major determinant of cancer patient mortality. Mounting evidence favors a strong positive role for TGF-β in human cancer progression. The complex pattern on cross-talk of TGF-β and the related other signaling pathways is an important area of investigation that will ultimately contribute to understanding of the bifunctional role of TGF-β in cancer progression. This review summarizes some of the current understanding of TGF-β signaling with a major focus in its contribution to the tumor cell invasion and metastasis. Five issues are addressed in this review: (1) TGF-β signaling, (2) TGF-β and EMT, (3) TGF-β and MMP, (4) TGF-β and Ras, and (5) Role of TGF-β in invasion and metastasis. Due to the bifunctional cellular effects of TGF-β, as a tumor promoter and a tumor suppressor, more precisely defined TGF-β signaling pathways need to be elucidated. According to the current literature, TGF-β is clearly a major factor stimulating tumor progression through a complex spectrum of the interplay and cross-talk between various signaling molecules. Understanding the role of TGF-β in invasion and metastasis will provide valuable information on establishing strategies to manipulate TGF-β signaling which should be a high priority for the development of anti-metastatic therapeutics.
목차
INTRODUCTION
CONCLUSIONS
ACKNOWLEDGEMENTS
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-513-016245940