지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.4
- 수록면
- 274 - 281 (8page)
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Purpose: Many cancers, including pancreatic cancer, harbor defects in TGFβ signaling and are resistant to TGFβ mediated growth inhibition. In addition, the expression of the p53 gene and mutations in K-ras might play an important role in the multistep carcinogenesis of pancreatic cancer. This study examined the expression level of TGFβ1, TGFβ receptorⅡ (TβRⅡ), p53 protein and K-ras mutation in pancreatic cancer, along with their role and clinical significance.
Methods: The overexpression of TGFβ1, TβRⅡ and p53 protein was evaluated using an immunohistochemical assay. The K-ras mutation was analyzed by PCR-RFLP in the surgical resected pancreatic tissue from 26 pancreatic ductal adenocarcinomas and 5 normal pancreases.
Results: Immunohistochemical analysis of TGFβ1 and Tβ RⅡ revealed positive immunostaining in 73.1% and 76.9% of the tumors, respectively, which were significantly higher than the normal pancreas (P=0.008). The p53 protein was positive in none of the 5 normal ducts and 16 out of 26 (61.5%) pancreatic carcinoma specimens. The K-ras mutation was positive in none of the 5 normal ducts, and in 20 of the 26 pancreatic carcinoma specimens (76.9%). The presence of TGFβ1 and TβRⅡ in the cancer samples was significantly associated with node metastasis, advanced tumor stage (P＜0.01), and a short survival time (P＜0.05). The p53-positive pancreatic cancers showed a significantly lower survival rate than those with p53-negative tumors (P＜0.05). There was no correlation between K-ras mutations and the survival rates.
Conclusion: The detection of K-ras mutations and TGFβ1, TβRⅡ and p53 protein overexpression can predict the prognosis of pancreatic carcinoma patients.
Methods: The overexpression of TGFβ1, TβRⅡ and p53 protein was evaluated using an immunohistochemical assay. The K-ras mutation was analyzed by PCR-RFLP in the surgical resected pancreatic tissue from 26 pancreatic ductal adenocarcinomas and 5 normal pancreases.
Results: Immunohistochemical analysis of TGFβ1 and Tβ RⅡ revealed positive immunostaining in 73.1% and 76.9% of the tumors, respectively, which were significantly higher than the normal pancreas (P=0.008). The p53 protein was positive in none of the 5 normal ducts and 16 out of 26 (61.5%) pancreatic carcinoma specimens. The K-ras mutation was positive in none of the 5 normal ducts, and in 20 of the 26 pancreatic carcinoma specimens (76.9%). The presence of TGFβ1 and TβRⅡ in the cancer samples was significantly associated with node metastasis, advanced tumor stage (P＜0.01), and a short survival time (P＜0.05). The p53-positive pancreatic cancers showed a significantly lower survival rate than those with p53-negative tumors (P＜0.05). There was no correlation between K-ras mutations and the survival rates.
Conclusion: The detection of K-ras mutations and TGFβ1, TβRⅡ and p53 protein overexpression can predict the prognosis of pancreatic carcinoma patients.
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