지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 459 - 464 (6page)
이용수
초록· 키워드
오류제보하기
Exendin-4 derived from the venom of the Gila monster lizard (Heloderma suspectum) shows structural relationship to the important incretin hormone, glucagon like peptide-1. In addition to stimulating insulin secretion, exendin-4 has also been known to stimulate β-cell proliferation and islet mass increase. Although these beneficial effects on diabetes have been suggested, it has not yet been examined the effects of exendin-4 on β-cell destruction by harmful stimuli such as cytokines and reactive radicals. The aim of this study was to investigate whether exendin-4 would confer resistance to the cytotoxic effects of nitric oxide (NO), preserving the viability of rat insulinoma RINm5F cells. Exposure of RINm5F cells to sodium nitroprusside (SNP), an intracellular NO generator, decreased cell viability denoted by MTT and FACS analysis. The intracellular level of superoxide radical and a product of lipid peroxidation, malondialdehyde (MDA) were significantly increased by treatment of SNP for 12 hours. Exendin-4 increased RINm5F cellular viability and markedly attenuated SNP-induced cell death in a dose-dependent manner. The SNP-induced NO and superoxide radical production, MDA production and DNA damage were also significantly decreased by pretreatment of exendin-4. Thus, our results suggest that exendin-4 has protective effects against NO-induced cell death via inhibiting detrimental reactive radical production in insulin-producing RINm5F cells.
목차
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Bach / 1994 / Insulin-dependent diabetes mellitus as an autoimmune disease endocri (l) : 516 ~ 542
2. [학술지(정기간행물)] - Bindokas, V.P / 1996 / Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine 15 : 1324 ~ 1336
3. [학술지(정기간행물)] - Blonde, L / 2006 / What are incretins, and how will they influence the management of type 2 diabetes 12 : 14 ~ 16
4. [학술지(정기간행물)] - Cnop, M / 2005 / Mechanisms of pancreatic a-cell death in type1 and type 2 diabetes 54 : S97 ~ S107
5. [학술지(정기간행물)] - Drucker, D.J / 2003 / Enhancing incretin action for the treatment of type 2 diabetes 26 : 2929 ~ 2940
2. [학술지(정기간행물)] - Bindokas, V.P / 1996 / Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine 15 : 1324 ~ 1336
3. [학술지(정기간행물)] - Blonde, L / 2006 / What are incretins, and how will they influence the management of type 2 diabetes 12 : 14 ~ 16
4. [학술지(정기간행물)] - Cnop, M / 2005 / Mechanisms of pancreatic a-cell death in type1 and type 2 diabetes 54 : S97 ~ S107
5. [학술지(정기간행물)] - Drucker, D.J / 2003 / Enhancing incretin action for the treatment of type 2 diabetes 26 : 2929 ~ 2940
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
광화학적으로 유발한 뇌허혈모델에서 펩타이드호르몬 Exendin-4에 의한 치아이랑의 신경세포재생
대한체질인류학회 학술대회 연제 초록
2009 .05
-
Scutellaria Bicalensis extract prevents cytokine-induced nitric oxide formation and –cell death in RINm5F cells
대한동의병리학회 학술대회논문집
2003 .07
-
SNAP 유도성 RINm5F 세포 독성에 대한 黃連 추출물의 방어효과
대한한의학회지
2003 .06
-
Sodium nitroprusside induces autophagic cell death in glutathione-depleted osteoblasts
Molecular & cellular toxicology
2010 .01
-
췌장 베타세포에서 스트렙토조토신으로 유도한 인슐린 의존형 당뇨병 실험 모델
약학회지
1997 .01
-
싸이토카인에 의한 췌장 ${\beta}$세포 독성에 대한 동충하초(冬蟲夏草) 추출물의 보호 효과
동의생리병리학회지
2008 .01
-
Cell viability analysis
대한견주관절의학회 학술대회논문집
2015 .04
-
Generation of Insulin-Producing Human Mesenchymal Stem Cells Using Recombinant Adeno-Associated Virus
Yonsei Medical Journal
2007 .01
-
Cell Cycle, Cell Death and Apoptosis
대한핵의학회 연수교육
2002 .01
-
Differences in Their Proliferation and Differentiation between B-1 and B-2 Cell
Immune Network
2006 .03
-
Differentiation of Human Embryonic Stem Cells into Insulin-Producing Cell Clusters
대한생식의학회 학술대회
2006 .01
-
The Protective Effects of Insulin on Hydrogen Peroxide-Induced Oxidative Stress in C6 Glial Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2009 .01
-
Cell Death and Liver Disease
Gut and Liver
2020 .01
-
시호 약침제제의 자유기 소거능 및 지질과산화 억제효능에 관한 연구
대한침구의학회지
1998 .01
-
Cell Death and Bacterial Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2013 .06
-
Role of Lipid Peroxidation on H₂O₂-Induced Renal Cell Death in Cultured Cells and Freshly Isolated Cells
대한의생명과학회지
2002 .12
-
Expression of Hepatitis B Virus X Protein in Hepatocytes Suppresses CD8+ T Cell Activity
Immune Network
2010 .08
-
감마방사선에 의한 암세포의 세포손상에 관한 연구
대한방사선협회지
2004 .01
-
In Vitro Differentiation of Human Adipose Tissue-derived Stem Cells into Insulin Producing Cells
대한생식의학회 학술대회
2006 .01
-
배아줄기세표의 인슐린 분비세포로의 유도 분화에 대한 연구
대한불임학회지
2004 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-510-016250059