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초록·키워드
An investigation was conducted to examine the chemopreventive effects of Korean ginseng (Panax ginseng C.A. Mayer) extract (KGE) on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH). Five-week-old male F344 rats were fed with a diet containing 0.5% or 1% of KGE for 8 weeks. During the initial 2 weeks, the rats were subcutaneously injected with DMH (30 ㎎/㎏) or saline 4 times to induce colonic ACF. The ACF formed on the colonic mucosa were examined after staining with methylene blue. Four-times treatment with DMH induced mean 265.8 ± 48.3 ACF/colon composed of total 608.8 ± 110.9 aberrant crypts (AC)/colon. The numbers of ACF and AC induced by DMH were significantly decreased to 190.3±49.9 and 467.6±127.3, respectively, by treatment with 0.5% KGE, and further reduced to 168.1 and 389.8±125.1 by 1% KGE. Especially, the number of large ACF (≥4 AC/ACF), that had been suggested to possess a greater tumorigenic potential than small ACF (≤3 AC/ACF), was greatly suppressed from 39.9 ± 10.6 ACF/colon in control to 26.2± 11.1 ACF/colon in 1% KGE-treated group. These results suggest that KGE exert a chemopreventive effect on the DMH-induced colon cancer by inhibiting the development of ACF and AC in the rats.
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UCI(KEPA) : I410-ECN-0101-2009-510-016362767
