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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.3
- 수록면
- 61 - 66 (6page)
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An investigation was conducted to examine the chemopreventive effects of Korean ginseng (Panax ginseng C.A. Mayer) extract (KGE) on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH). Five-week-old male F344 rats were fed with a diet containing 0.5% or 1% of KGE for 8 weeks. During the initial 2 weeks, the rats were subcutaneously injected with DMH (30 ㎎/㎏) or saline 4 times to induce colonic ACF. The ACF formed on the colonic mucosa were examined after staining with methylene blue. Four-times treatment with DMH induced mean 265.8 ± 48.3 ACF/colon composed of total 608.8 ± 110.9 aberrant crypts (AC)/colon. The numbers of ACF and AC induced by DMH were significantly decreased to 190.3±49.9 and 467.6±127.3, respectively, by treatment with 0.5% KGE, and further reduced to 168.1 and 389.8±125.1 by 1% KGE. Especially, the number of large ACF (≥4 AC/ACF), that had been suggested to possess a greater tumorigenic potential than small ACF (≤3 AC/ACF), was greatly suppressed from 39.9 ± 10.6 ACF/colon in control to 26.2± 11.1 ACF/colon in 1% KGE-treated group. These results suggest that KGE exert a chemopreventive effect on the DMH-induced colon cancer by inhibiting the development of ACF and AC in the rats.
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UCI(KEPA) : I410-ECN-0101-2009-510-016362767