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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.9
- 수록면
- 239 - 243 (5page)
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초록· 키워드
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A long-term carcinogenicity study is required to assess the safety of new drug candidates. This classical toxicological method has been using rats and mice as animal systems. The International Conference on Harmonization (ICH) of technical requirements of pharmaceuticals for human use have recommended one long-term rodent carcinogenicity test using rat and one other supplementary mouse study such as an initiation-promotion model, a transgenic model or a neonatal model. This study was carried out to develop an initiation-promotion liver carcinogenicity model using a mouse. Twelve-day old FVB/NJ mice were intraperitoneally injected with diethyl nitrosamine (DEN) as an initiator and orally administered with 2-acetlyaminofluorene (2-AAF) as a promoter. And o-galactosamine (DGA) was injected as a stimulator for tumorigenic progress. Basophilic foci in the liver were observed 16 weeks after initiation. The incidence of hepatocellular adenoma was increased in animals 2-AAF-treated at 20 and 26 weeks after initiation. The tumor incidence in 2-AAF-treated animals were significantly higher than with the untreatment and initiator treatment control groups. Hepatocellular carcinoma (HCC) was found in some cases. These results suggest that two-step neonatal FVB/NJ mouse model could be useful for carcinogenic assay of new drug candidates.
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재료 및 방법
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고찰
감사의 글
참고문헌
참고문헌 (14)
참고문헌 신청
Asaoka, Y , 2005 , Intraperitoneal injection of D-galactosamine provides a potent cell proliferation stimulus for the detection of initiation activities of chemicals in rat liver 25 : 554 ~ 561
Decker , 1974 , key roleof the nucleotide deficiency period in the pathogenesis of cellinjury and cell death. Rev. Physiol. Biochem. Pharmacol. 71 : 77 ~ 106
Della porta , 1987 , Two-stageliver carcinogenesis in the mouse. Toxicol. Pathol. 15 : 229 ~ 233
Evert, M , 2002 , Morphology and morphometric investigation of hepatocellular preneoplastic lesions and neoplasms in connexin32- deficient mice 23 : 697 ~ 703
Glodworthy, T.L , 2002 , Quantitation of the cancer process in C57BL, 6J, B6C3F1and C3H, HeJ mice 30 : 97 ~ 105
Decker , 1974 , key roleof the nucleotide deficiency period in the pathogenesis of cellinjury and cell death. Rev. Physiol. Biochem. Pharmacol. 71 : 77 ~ 106
Della porta , 1987 , Two-stageliver carcinogenesis in the mouse. Toxicol. Pathol. 15 : 229 ~ 233
Evert, M , 2002 , Morphology and morphometric investigation of hepatocellular preneoplastic lesions and neoplasms in connexin32- deficient mice 23 : 697 ~ 703
Glodworthy, T.L , 2002 , Quantitation of the cancer process in C57BL, 6J, B6C3F1and C3H, HeJ mice 30 : 97 ~ 105
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