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자료유형
학술저널
저자정보
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한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.21 No.2
발행연도
2005.6
수록면
149 - 157 (9page)

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The purpose of this study was to confirm the improving effect of the Hwalgidan SJ-101 on hypercholesterolemia and ensuing atherosclerosis in rabbits. Male New Zealand White rabbits were fed on only hypercholesterol diet containing 1% cholesterol and 2% corn oil for 2 weeks, and then Hwalgidan SJ-101 (1% or 3%) or lovastatin (0.002%) were added to the diet for additional 8 weeks. Blood cholesterol levels, especially low-density lipoproteins (LDL), were greatly increased by 2-week feeding on the hypercholesterol diet to 25 - 35 fold of control, and further increased during additional 8 weeks, in contrast to reduction of high-density lipoproteins (HDL). Such a hypercholesterolemia was significantly reduced by 8-week feeding on Hwalgidan SJ-101 or lovastatin. In addition, the hypercholestrol diet-induced decrease in HDL and increase in triglycerides were reversed by Hwalgidan SJ-101 or lovastatin. Moreover, thick atheromatous plaques on the wall of aorta of rabbits fed on hypercholesterol diet were markedly attenuated by Hwalgidan SJ-101 or lovastatin, leading to the decreases in atherosclerosis indices to 2.0, respectively, from 2.75 of rabbits fed on hypercholesterol diet alone. In addition, Hwalgidan SJ-101 lowered lipid deposition in hepatocytes, showing restricted distribution of foamy hepatocytes. Interestingly, however, lovastatin caused hepatic centrilobular congestion, leading to great increase in serum alanine transaminase and aspartate transaminase activities, in contrast to normal levels in Hwalgidan SJ-101-treated animals. In conclusion, the results suggest that Hwalgidan SJ-101 improves hyperlipidemia and ensuing atherosclerosis, without hepatotoxicity, probably by both controlling lipid metabolism and reducing free radical reactions.

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