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자료유형
학술저널
저자정보
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.24 No.1
발행연도
2008.3
수록면
51 - 58 (8page)

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The present study was designed to explore the immunotoxic effects of orally administered aluminum (Al) on pregnant rats (n = 60) and their growing fetuses and consequently on the animal wealth. The animals were randomly allocated into three equal groups of 20 rats each. The first group has no treatment and kept as a control (G1). The second and third groups of pregnant rats were treated orally with aluminum chloride at 345 ㎎/㎏ b.wt. The second group (G2) received the tested compound from the 6<SUP>th</SUP> day of gestation to the end of weaning, whereas the third group (G3) received the tested compound from the 15<SUP>th</SUP> day of gestation to the end of weaning. Control and treated animals (dams and offspring) were immunized ip with (0.5 ml) 20% sheep red blood cell (SRBC) suspension seven days before the end of experiments. At the end of exposure, ten dams and ten offspring from each group were used for assessment of cell-mediated immunity and a similar number of animals were sacrificed for evaluating the humoral immune response and serum protein profile. Aluminum chloride exposure of dams (G₂& G₃) caused significant suppression of both cell mediated and humoral immune responses in the obtained offsprings compared to the control group (G₁) without any significant effect on the immune responses of these dams. Moreover, the serum total globulins, albumin/ globulin (A/G) ratio and gamma globulin fraction were significantly decreased in the treated dam's offsprings compared to the corresponding controls while the serum total protein and all serum protein fractions showed non significant difference between the control and treated dams and between the two treated dam groups themselves. There were no histopathological changes observed in thymus, spleen and liver of the control and treated dams. Thymus of treated dam's offsprings (G2) showed lymphoid depletion in both cortex and medulla. Their spleens showed lymphoid depletion in the white pulps and congestion with hemosiderosis in the red pulps. Liver of treated dam's offsprings showed dilation and congestion of its central vein with degenerative changes in the hepatocytes. These histopathological changes were more severe in G2 than in G3 offsprings. It can be concluded that gestational and/ or lactation exposure of pregnant dams to Al chloride caused suppression of both cellular and humoral immune responses of their offsprings.
#Aluminum chloride #Immunotoxicity #Rats #Humoral and cell mediated immune response #Thymus #Spleen #Liver

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENT
REFERENCES

참고문헌 (49)

참고문헌 신청
A.T.S.D.R , 2006 , Toxicological Profile for Aluminum (Update). Draft for public comment. Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services , Atlanta, GA google schola Bancroft, J.D , 1996 , Theory and practice of histological techniques. 4th , New York, Churchill, Livingstone google schola Barr, R.J , 1993 , Histocytic reaction associated with topical aluminum chloride (Drysol reaction) , J. Dermatol. Surg. Oncol 19 : 1017 ~ 1021 google schola Bergfors, E , 2005 , Nineteen cases of persistent pruritic nodules and contact allergy to aluminium after injection of commonly used aluminum- adsorbed vaccines , Eur. J. Pediatr 164 : 691 ~ 697 google schola Bomford,R , 1980 , The comparative selectivity of adjuvants for humoral and cell-mediated immunity. Clin , Exp. Immunol : 435 ~ 441 google schola

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