지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 239 - 250 (12page)
이용수
초록· 키워드
오류제보하기
ObjectiveMaternal malnutrition affects the growth and metabolic health of the offspring. Little is known about the longtermeffect on metabolic indices of epigenetic changes in the brain caused by maternal diet. Thus, we explored theeffect of maternal food restriction during pregnancy on metabolic profiles of the offspring, by evaluating the DNAmethylation of hypothalamic appetite regulators at 3 weeks of age. MethodsSprague-Dawley rats were divided into 2 groups: a control group and a group with a 50% food-restricted (FR) dietduring pregnancy. Methylation and expression of appetite regulator genes were measured in 3-week-old offspringusing pyrosequencing, real-time polymerase chain reaction, and western blotting analyses. We analyzed therelationship between DNA methylation and metabolic profiles by Pearson’s correlation analysis. ResultsThe expression of pro-opiomelanocortin (POMC) decreased, whereas DNA methylation significantly increased in maleoffspring of the FR dams, compared to the male offspring of control dams. Hypermethylation of POMC was positivelycorrelated with the levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol in3-week-old male offspring. In addition, there were significant positive correlations between hypermethylation ofPOMC and the levels of triglycerides, HDL-C, and leptin in 6-month-old male offspring. ConclusionOur findings suggest that maternal food restriction during pregnancy influences the expression of hypothalamicappetite regulators via epigenetic changes, leading to the development of metabolic disorders in the offspring.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Barker DJ / 1993 / Type 2(non-insulin-dependent)diabetes mellitus, hypertension and hyperlipidaemia(syndrome X) : relation to reduced fetal growth / Diabetologia 36:62~67
Barker DJ / 2004 / The developmental origins of chronic adult disease / Acta Paediatr Suppl 93:26~33
Coupé B / 2009 / The timing of"catch-up growth"affects metabolism and appetite regulation in male rats born with intrauterine growth restriction / Am J Physiol Regul Integr Comp Physiol 297:R813~24
Breier BH / 2001 / Fetal programming of appetite and obesity / Mol Cell Endocrinol 185:73~79
권은진 / 2017 / What is fetal programming?: a lifetime health is under the control of in utero health / Obstetrics & Gynecology Science 60(6):506~519
Barker DJ / 2004 / The developmental origins of chronic adult disease / Acta Paediatr Suppl 93:26~33
Coupé B / 2009 / The timing of"catch-up growth"affects metabolism and appetite regulation in male rats born with intrauterine growth restriction / Am J Physiol Regul Integr Comp Physiol 297:R813~24
Breier BH / 2001 / Fetal programming of appetite and obesity / Mol Cell Endocrinol 185:73~79
권은진 / 2017 / What is fetal programming?: a lifetime health is under the control of in utero health / Obstetrics & Gynecology Science 60(6):506~519
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