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논문 기본 정보

자료유형
학술저널
저자정보
Ryu Ki-Jin (Department of Obstetrics and Gynecology Korea University Anam Hospital Korea University College of Medicine Seoul Korea.) Wi Won Young (Department of Obstetrics and Gynecology Korea University Guro Hospital Korea University College of Medicine Seoul Korea.) Nam Seunghyun (Department of Obstetrics and Gynecology Korea University Anam Hospital Korea University College of Medicine Seoul Korea.) Jeong Hye Gyeong (Department of Obstetrics and Gynecology Korea University Anam Hospital Korea University College of Medicine Seoul Korea.) Cho Geum Joon (Department of Obstetrics and Gynecology Korea University Guro Hospital Korea University College of Medicine Seoul Korea.) Park Hyuntae (Department of Obstetrics and Gynecology Korea University Anam Hospital Korea University College of Medicine Seoul Korea.) Kim Tak (Department of Obstetrics and Gynecology Korea University Anam Hospital Korea University College of Medicine Seoul Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.38 No.14
발행연도
2023.4
수록면
1 - 10 (10page)
DOI
10.3346/jkms.2023.38.e111

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Background: To investigate the relationship between polycystic ovary syndrome (PCOS) in Korean women and childhood growth and obesity of their offspring. Methods: This longitudinal case-control study using the Korean National Health Insurance claims database and the National Health Screening Program for Infants and Children database included women who delivered singletons between January 2007 and December 2008. Offspring’s body mass index (BMI) measurements taken between 42 and 80 months of age were compared according to a maternal history of PCOS. Results: Among a total of 131,805 participants, 1,213 women had a history of PCOS and 130,592 women did not. Female offspring aged 66–80 months born to women with PCOS had significantly higher BMI than those born to women without PCOS; there was no significant difference in that of male offspring regardless of maternal PCOS. In the generalized estimating equation and multivariable logistic regression analyses, the female offspring born to women with PCOS had a significantly higher risk of obesity during the age of 42–54 and 66–80 months (odds ratio [OR], 1.6; 95% confidence interval [CI], 1.09–2.21 and OR, 1.5; 95% CI, 1.05–2.15, respectively), than those born to women without PCOS, after adjusting for several confounding factors. Conclusion: Maternal PCOS is independently associated with an increased incidence of childhood obesity in female offspring among Korean women. Women with PCOS should consider the risk of early childhood obesity in their daughters, even if they maintain a healthy weight themselves.

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