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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 420 - 428 (9page)
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PurposePolycystic ovary syndrome (PCOS) is a gynecological endocrine disorder that is characterized by disturbances in ovarianblood flow and angiogenesis. The aim of this study was to determine the association of vascular endothelial growthfactor (VEGF) and thrombospondin-1 (TSP-1) serum levels with the body mass index (BMI) in patients with PCOScompared with healthy subjects. MethodsThe study was conducted with 80 subjects in 3 PCOS groups, including normal weight, overweight, and obese PCOSgroups, and a control group of healthy subjects (n=20). The participants in all groups completed a questionnairecomprising sociodemographic and obstetric questions. The PCOS diagnosis in the study subjects was confirmed basedon the Rotterdam criteria, BMI was determined according to the World Health Organization guidelines, and the lipidaccumulation product index was calculated for all groups. Venous blood samples were collected from all participantsafter fasting to measure the serum levels of fasting blood glucose (FBG), lipids, insulin, VEGF, TSP-1, and leptin. ResultsOur findings showed that the serum VEGF level was significantly higher in the normal BMI PCOS group than thatin the control group (P=0.03), and the TSP-1 level was significantly lower in the obese PCOS group than that in thecontrol group (P=0.04). ConclusionsOur study demonstrated that alterations in VEGF and TSP-1 concentrations are dependent on BMI. Because abnormalovarian angiogenesis is considered to be the main feature of PCOS, the study of ovarian angiogenic imbalance isproposed as a new tool for PCOS diagnosis and management.
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참고문헌 (33)
참고문헌 신청
Qu J / 2015 / The higher response of vascular endothelial growth factor and angiotensin-ii to human chorionic gonadotropin in women with polycystic ovary syndrome / Int J Fertil Steril 8:373~378
Peitsidis P / 2010 / Role of vascular endothelial growth factor in women with PCO and PCOS : a systematic review / Reprod Biomed Online 20:444~452
Diamanti-Kandarakis E / 2007 / Role of obesity and adiposity in polycystic ovary syndrome / Int J Obes 31(Suppl 2):S8~S13
Jin CH / 2015 / Body fat distribution and its associated factors in Korean women with polycystic ovary syndrome / J Obstet Gynaecol Res 41:1577~1583
El Hayek S / 2016 / Poly cystic ovarian syndrome : an updated overview / Front Physiol 7:124
Peitsidis P / 2010 / Role of vascular endothelial growth factor in women with PCO and PCOS : a systematic review / Reprod Biomed Online 20:444~452
Diamanti-Kandarakis E / 2007 / Role of obesity and adiposity in polycystic ovary syndrome / Int J Obes 31(Suppl 2):S8~S13
Jin CH / 2015 / Body fat distribution and its associated factors in Korean women with polycystic ovary syndrome / J Obstet Gynaecol Res 41:1577~1583
El Hayek S / 2016 / Poly cystic ovarian syndrome : an updated overview / Front Physiol 7:124
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