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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 253 - 260 (8page)
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ObjectiveThe purpose of the current study was to compare the circulating levels of visfatin between women with polycysticovary syndrome (PCOS) and those without PCOS and to assess the correlations between visfatin levels and variousparameters. MethodsThis case-control study recruited 74 PCOS patients and 74 age- and body mass index (BMI)-matched controls. Serumvisfatin levels were evaluated using the enzyme-linked immunosorbent assay. Women with PCOS were divided into2 subgroups based on the presence of clinical or biochemical hyperandrogenism. The possible differences in serumvisfatin levels between the hyperandrogenic and non-hyperandrogenic groups were also assessed. ResultsVisfatin levels in PCOS patients were similar to those in the controls. However, hyperandrogenic patients hadsignificantly higher mean serum visfatin levels than those in non-hyperandrogenic patients (3.87 ng/mL; 95%confidence intervals [CIs], 3.09–4.85 in hyperandrogenic group vs. 2.69 ng/mL; 95% CIs, 2.06–3.52 in nonhyperandrogenicgroup; P=0.038). In women with PCOS, visfatin levels positively correlated with BMI (r=0.23; P=0.047)and the log free androgen index (FAI) (r=0.27; P=0.021) and negatively correlated with high-density lipoprotein(HDL) cholesterol levels (r=−0.37; P=0.025). Except for HDL cholesterol levels, these correlations were also observed incontrols. ConclusionVisfatin levels in PCOS patients were similar to those in the controls. However, hyperandrogenic patients showedsignificantly higher serum visfatin levels than those of non-hyperandrogenic patients, and visfatin had a positivelinear correlation with FAI in both PCOS patients and controls.
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참고문헌 (39)
참고문헌 신청
Conway G / 2014 / The polycystic ovary syndrome: a position statement from the European Society of Endocrinology / Eur J Endocrinol 171:P1~P29
Dumesic DA / 2015 / Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome / Endocr Rev 36:487~525
Berndt J / 2005 / Plasma visfatin concentrations and fat depot-specific mRNA expression in humans / Diabetes 54:2911~2916
Tan BK / 2006 / Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: parallel increase in plasma visfatin / J Clin Endocrinol Metab 91:5022~5028
Cheng KH / 2008 / Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease / Int J Obes (Lond) 32:268~274
Dumesic DA / 2015 / Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome / Endocr Rev 36:487~525
Berndt J / 2005 / Plasma visfatin concentrations and fat depot-specific mRNA expression in humans / Diabetes 54:2911~2916
Tan BK / 2006 / Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: parallel increase in plasma visfatin / J Clin Endocrinol Metab 91:5022~5028
Cheng KH / 2008 / Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease / Int J Obes (Lond) 32:268~274
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