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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 279 - 285 (7page)
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초록· 키워드
오류제보하기
Although retinoic acid has been known as either anti-inflammatory or pro-inflammatory molecule, depending on the cell type, its exact role in mature human neutrophils has not been fully explored. In this study, we investigate the effects of retinoic acid on neutrophil apoptosis and the associated mechanism and found that 9-cis retinoic acid (9CRA) significantly inhibits the spontaneous apoptosis of neutrophils. Its effect is increased by co-treatment with TNF-α (P＜0.05). The 9CRA-induced inhibition is blocked by the following enzyme inhibitors: Ly 294002, phosphoinoside (PI)-3 kinase inhibitor, U73122, a phospholipase C (PLC) inhibitor, PP2, Src family protein inhibitor, SB202190, p38 MAPK inhibitor, and BAY-11-7085, NF-κB inhibitor. This study also demonstrates that all-trans retinoic acid suppresses spontaneous apoptosis, similar to the mechanism of inhibition exhibited by 9CRA. Phosphorylation of p38 MAPK decreases by 9CRA treatment. Iκ-Bα is degraded until 30 minutes after a time-dependent 9CRA treatment, but degradation can be inhibited by Ly 294002. These results indicate that 9CRA decreases p38 MAPK activation, induces NF-κB activation via PI-3 kinase, and also blocks cleavage of caspase 3. As these findings suggest, 9CRA has a molecular mechanism which may help pro-inflammatory response by blocking neutrophil apoptosis.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
Acknowledgements
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Alvarado-Kristensson, M / 2004 / p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils / J Exp Med. 199 : 449 ~ 458
2. [학술지(정기간행물)] - Antonyak, MA / 2003 / Activation of the Ras-ERK pathway inhibits retinoic acidinduced stimulation of tissue transglutaminase expression in NIH3T3 cells / J Biol Chem. 278
3. [학술지(정기간행물)] - Aoshiba, K / 1999 / Role of p38-mitogen-activated protein kinase in spontaneous apoptosis of human neutrophils / J Immunol. 162 : 1692 ~ 1700
4. [학술지(정기간행물)] - Babina, M / 2001 / Retinoic acid up-regulates myeloid ICAM-3 expression and function in a cell-specific fashion-evidence for retinoid signaling pathways in the mast cell lineage / J Leukoc Biol. 69 : 361 ~ 372
5. [학술지(정기간행물)] - Babina, M / 2003 / All-trans retinoic acid down-regulates expression and function of beta2 integrins by human monocytes: opposite effects on monocytic cell lines / Eur J Immunol. 33 : 616 ~ 625
2. [학술지(정기간행물)] - Antonyak, MA / 2003 / Activation of the Ras-ERK pathway inhibits retinoic acidinduced stimulation of tissue transglutaminase expression in NIH3T3 cells / J Biol Chem. 278
3. [학술지(정기간행물)] - Aoshiba, K / 1999 / Role of p38-mitogen-activated protein kinase in spontaneous apoptosis of human neutrophils / J Immunol. 162 : 1692 ~ 1700
4. [학술지(정기간행물)] - Babina, M / 2001 / Retinoic acid up-regulates myeloid ICAM-3 expression and function in a cell-specific fashion-evidence for retinoid signaling pathways in the mast cell lineage / J Leukoc Biol. 69 : 361 ~ 372
5. [학술지(정기간행물)] - Babina, M / 2003 / All-trans retinoic acid down-regulates expression and function of beta2 integrins by human monocytes: opposite effects on monocytic cell lines / Eur J Immunol. 33 : 616 ~ 625
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UCI(KEPA) : I410-ECN-0101-2010-510-001484577