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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 122 - 125 (4page)
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초록· 키워드
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House dust mite (HDM) as a major allergen and damage-associated molecular pattern (DAMP) such as S100A8 and S100A9 trigger the pathogenesis and severity of allergic disease such as asthma. Regulation of neutrophil apoptosis is an important immune response and its dysregulation is involved in pathogenesis of allergic diseases. In this study, we examined the effects of HDM, S100A8 and S100A9 on spontaneous apoptosis of normal neutrophils. We considered the importance of the difference between in vitro and in vivo results and developed a new in vitro system consisting of a combination of immune cells and T helper (Th) cytokines. Extract of Dermatophagoides pteronyssinus (DP), S100A8, and S100A9 inhibited neutrophil apoptosis in culture of neutrophils alone without other leukocytes. DP and S100A8 more strongly suppressed neutrophil apoptosis in combinations of neutrophils, eosinophils, lymphocytes or monocytes than in a culture of neutrophils alone. Anti-apoptotic effect of S100A9 in the mixture of immune cells was similar to that in neutrophils. DP, S100A8, and S100A9 blocked neutrophil apoptosis, regardless of pretreatment with a T helper (Th) 1 cytokine (IFN-γ), Th2 cytokines (IL-4 and IL-10), a Th9 cytokine (IL-9), a Th17 cytokine (IL-17), a Treg-producing cytokine (TGF-β). These findings may enable elucidation of allergy pathogenesis due to HDM and DAMP.
목차
REFERENCES
참고문헌 (11)
참고문헌 신청
[학술지(정기간행물)] - Donato R / 2013 / Functions of S100 proteins / Curr Mol Med 13 : 24 ~ 57
[학술지(정기간행물)] - Gaffin JM / 2009 / The role of indoor allergens in the development of asthma / Curr Opin Allergy Clin Immunol 9 : 128 ~ 135
[학술지(정기간행물)] - 강보경 / 2014 / The House dust Mite Allergen, Dermatophagoides pteronyssinus Regulates the Constitutive Apoptosis and Cytokine Secretion of Human Eosinophils / 대한의생명과학회지 20 (1) : 39 ~ 42
[학술지(정기간행물)] - Kemp AS / 2009 / Allergic rhinitis / Paediatr Respir Rev 10 : 63 ~ 68
[학술지(정기간행물)] - Kim DH / 2015 / House dust mite allergen regulates constitutive apoptosis of normal and asthmatic neutrophils via Toll-like receptor 4 / PLoS One
[학술지(정기간행물)] - Gaffin JM / 2009 / The role of indoor allergens in the development of asthma / Curr Opin Allergy Clin Immunol 9 : 128 ~ 135
[학술지(정기간행물)] - 강보경 / 2014 / The House dust Mite Allergen, Dermatophagoides pteronyssinus Regulates the Constitutive Apoptosis and Cytokine Secretion of Human Eosinophils / 대한의생명과학회지 20 (1) : 39 ~ 42
[학술지(정기간행물)] - Kemp AS / 2009 / Allergic rhinitis / Paediatr Respir Rev 10 : 63 ~ 68
[학술지(정기간행물)] - Kim DH / 2015 / House dust mite allergen regulates constitutive apoptosis of normal and asthmatic neutrophils via Toll-like receptor 4 / PLoS One
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UCI(KEPA) : I410-ECN-0101-2016-510-001658773