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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 152 - 159 (8page)
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초록· 키워드
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Der p 2, which is a major allergen of house dust mite, plays an important role in the pathogenesis of allergic disease. There is controversy regarding whether Der p 2 binds to Toll-like receptor 4 (TLR4), and its inflammatory effect has not yet been elucidated. In the current study, we examined the interaction of Der p 2 with TLR4 and the effect of Der p 2 on cytokine release in THP-1 cells and lymphocytes. Among house dust mite extracts, recombinant TLR4 protein interacted with Der p 2. The overall structure of Der p 2 is characteristic of the immunoglobulin superfamily and contains ten β-strands, forming a β-cup fold with two anti-parallel β-sheets, and a short 310 helix. The two sheets can be separated, further allowing the formation of a large internal pocket, which is narrow and suitable for binding large flat molecules such as lipid-like molecules. Der p 2 caused increased secretion of IL-6, IL-8, and MCP-1, which are neutrophil survival factors, in human monocytic THP-1 cells in a time-dependent manner. Der p 2 also induces the release of cytokines in normal and allergic lymphocytes. Supernatant after treatment with Der p 2 inhibited neutrophil apoptosis. In coculture of lymphocytes with neutrophils, Der p 2 inhibited spontaneous apoptosis of allergic neutrophils. In summary, Der p 2 binds to TLR4 and induces an inflammatory response such as cytokine secretion in immune cells. These findings may enable elucidation of allergy pathogenesis by specific allergen of house dust mite.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
[학술지(정기간행물)] - Gaffin JM / 2009 / The role of indoor allergens in the development of asthma / Curr Opin Allergy Clin Immunol 9 : 128 ~ 135
[학술지(정기간행물)] - Hammad H / 2009 / House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells / Nat Med 15 : 410 ~ 416
[학술지(정기간행물)] - 강보경 / 2014 / The House dust Mite Allergen, Dermatophagoides pteronyssinus Regulates the Constitutive Apoptosis and Cytokine Secretion of Human Eosinophils / 대한의생명과학회지 20 (1) : 39 ~ 42
[학술지(정기간행물)] - Kemp AS / 2009 / Allergic rhinitis / Paediatr Respir Rev 10 : 63 ~ 68
[학술지(정기간행물)] - Kim DH / 2015 / House dust mite allergen regulates constitutive apoptosis of normal and asthmatic neutrophils via Toll-like receptor 4 10 : e0125983 ~
[학술지(정기간행물)] - Hammad H / 2009 / House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells / Nat Med 15 : 410 ~ 416
[학술지(정기간행물)] - 강보경 / 2014 / The House dust Mite Allergen, Dermatophagoides pteronyssinus Regulates the Constitutive Apoptosis and Cytokine Secretion of Human Eosinophils / 대한의생명과학회지 20 (1) : 39 ~ 42
[학술지(정기간행물)] - Kemp AS / 2009 / Allergic rhinitis / Paediatr Respir Rev 10 : 63 ~ 68
[학술지(정기간행물)] - Kim DH / 2015 / House dust mite allergen regulates constitutive apoptosis of normal and asthmatic neutrophils via Toll-like receptor 4 10 : e0125983 ~
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UCI(KEPA) : I410-ECN-0101-2016-510-001968081