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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.6
- 수록면
- 16 - 25 (10page)
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초록· 키워드
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TLRs are pattern recognition receptors (PRRs) whose cytoplasmic signalling domain is similar to that of IL-1. The extracellular domain of TLRs serve as the binding site of pathogen associated molecular patterns. TLRs are found on both plasma and endosomal membranes and they mainly exert their function by activating genes which lead to production of inflammatory factors. The latest TLR to be discovered, TLR10 is a unique TLR which exhibit anti-inflammatory properties. TLR10 is found on the plasma membrane with other TLRs namely TLR1, TLR2, TLR4, TLR5 and TLR6. Studies have revealed that TLR10 is found on the same gene cluster with TLR1 and TLR6 and is also a coreceptor of TLR2. Up to date, TLR10 is the only TLR which exhibit anti-inflammatory property. Previously, TLR10 was thought to be an “orphan receptor” but much recent studies have identified ligands for TLR10. Currently there is no review article on TLR10 that has been published. In this narrative review, we are going to give an account of TLR10, its functions mainly as an anti-inflammatory PRR and its possible applications as a target in therapeutics.
목차
ABSTRACT
INTRODUCTION
TLR10
BIOLOGICAL FUNCTIONS OF TLR10
LIGANDS FOR TLR10
POLYMORPHISM IN TLR10 AND RELATED DISEASES
TLR10 AS A TARGET IN THERAPEUTICS AND DIAGNOSTICS
CONCLUSION
REFERENCES
참고문헌 (49)
참고문헌 신청
Kumar H / 2011 / Pathogen recognition by the innate immune system / Int Rev Immunol 30:16~34
Moresco EM / 2011 / Toll-like receptors / Curr Biol 21:R488
Akira S / 2004 / Toll-like receptor signalling / Nat Rev Immunol 4:499~511
Akira S / 2003 / Toll-like receptor signaling / J Biol Chem 278:38105~38108
Nie L / 2018 / Toll-like receptors, associated biological roles, and signaling networks in non-mammals / Front Immunol 9:1523
Moresco EM / 2011 / Toll-like receptors / Curr Biol 21:R488
Akira S / 2004 / Toll-like receptor signalling / Nat Rev Immunol 4:499~511
Akira S / 2003 / Toll-like receptor signaling / J Biol Chem 278:38105~38108
Nie L / 2018 / Toll-like receptors, associated biological roles, and signaling networks in non-mammals / Front Immunol 9:1523
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UCI(KEPA) : I410-ECN-0101-2020-517-000894379