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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 2016.1
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The mammalian Toll-like receptor (TLR) family, consisting of 13 members, plays an important role in innate recognition of specific patterns of microbial products. TLR-dependent recognition subsequently causes an activation of antigen-specific adaptive immunity. TLR-mediated signaling pathways consist of two pathways that induce gene expression: the myeloid differentiation primary response gene 88 (MyD88)-dependent pathway and Toll/interleukin-1 receptor-domain containing adaptor protein-inducing interferon--dependent pathway. Synthetic TLR agonists, as well as TLR antagonists, affect and manipulate the host defense systems, and some of these immunomodulating agents may help to overcome intrinsic disturbances of the TLR system to offer new treatment options in urinary tract infection (UTI). Future studies are necessary to clarify additional associations between TLRs and severity of UTI, which may help in developing new treatment options.
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참고문헌 (42)
참고문헌 신청
Hansson GK / 2005 / Toll to be paid at the gateway to the vessel wall / Arterioscler Thromb Vasc Biol 25:1085~1087
Medzhitov R / 1997 / A human homologue of the Drosophila Toll protein signals activation of adaptive immunity / Nature 388:394~397
Takeda K / 2015 / Toll-like receptors / Curr Protoc Immunol 109:1~10
Wullt B / 2001 / P-fimbriae trigger mucosal responses to Escherichia coli in the human urinary tract / Cell Microbiol 3:255~264
Fischer H / 2005 / Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection / Eur J Immunol 36:267~277
Medzhitov R / 1997 / A human homologue of the Drosophila Toll protein signals activation of adaptive immunity / Nature 388:394~397
Takeda K / 2015 / Toll-like receptors / Curr Protoc Immunol 109:1~10
Wullt B / 2001 / P-fimbriae trigger mucosal responses to Escherichia coli in the human urinary tract / Cell Microbiol 3:255~264
Fischer H / 2005 / Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection / Eur J Immunol 36:267~277
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