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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 144 - 151 (8page)
이용수
초록· 키워드
오류제보하기
Graft-versus-host disease (GHVD) is a severe complication after allogeneic hematopoietic stem cell transplantation. The degree of inflammation in the gastrointestinal tract, a major GVHD target organ, correlates with the disease severity. Intestinal inflammation is initiated by epithelial damage caused by pre-conditioning irradiation. In combination with damages caused by donor-derived T cells, such damage disrupts the epithelial barrier and exposes innate immune cells to pathogenic and commensal intestinal bacteria, which release ligands for Toll-like receptors (TLRs). Dysbiosis of intestinal microbiota and signaling through the TLR/myeloid differentiation primary response gene 88 (MyD88) pathways contribute to the development of intestinal GVHD. Understanding the changes in the microbial flora and the roles of TLR signaling in intestinal GVHD will facilitate the development of preventative and therapeutic strategies.
목차
INTRODUCTION
ACUTE AND CHRONIC GVHD
GUT MICROBIOME AND INNATE IMMUNITY IN ACUTE INTESTINAL GVHD
MyD88-DEPENDENT EXPANSION OF MYELOID-DERIVED SUPPRESSOR CELLS (MDSCs) IN ACUTE INTESTINAL GVHD
CONCLUSION
REFERENCES
참고문헌 (68)
참고문헌 신청
Mohty, M., L. H. de, P. Ladaique, C. Faucher, N. Vey, D. Coso, A. M. Stoppa, J. A. Gastaut, and D. Blaise. 2005. The role of reduced intensity conditioning allogeneic stem cell transplantation in patients with acute myeloid leukemia: a donor vs no donor comparison. Leukemia 19: 916-920.
Poon, L. M., R. Bassett, Jr., G. Rondon, A. Hamdi, M. Qazilbash, C. Hosing, R. B. Jones, E. J. Shpall, U. R. Popat, Y. Nieto, L. L. Worth, L. Cooper, L. M. De, R. E. Champlin, and P. Kebriaei. 2013. Outcomes of second allogeneic hematopoietic stem cell transplantation for patients with acute lymphoblastic leukemia. Bone Marrow Transplant. 48: 666-670.
Demirer, T., L. Barkholt, D. Blaise, P. Pedrazzoli, M. Aglietta, A. M. Carella, J. O. Bay, F. Arpaci, G. Rosti, G. Gurman, D. Niederwieser, and M. Bregni. 2008. Transplantation of allogeneic hematopoietic stem cells: an emerging treatment modality for solid tumors. Nat. Clin. Pract. Oncol. 5: 256-267.
Dvorak, C. C., and M. J. Cowan. 2008. Hematopoietic stem cell transplantation for primary immunodeficiency disease. Bone Marrow Transplant. 41: 119-126.
Warren, E. H., N. Fujii, Y. Akatsuka, C. N. Chaney, J. K. Mito, K. R. Loeb, T. A. Gooley, M. L. Brown, K. K. Koo, K. V. Rosinski, S. Ogawa, A. Matsubara, F. R. Appelbaum, and S. R. Riddell. 2010. Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens. Blood 115: 3869-3878.
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UCI(KEPA) : I410-ECN-0101-2018-517-000885513