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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제19권 제1호
- 발행연도
- 2016.1
- 수록면
- 29 - 37 (9page)
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Purpose: The aim of our study was to establish a safe and convenient diagnostic method for acute gastrointestinal (GI) graft-versus-host disease (GVHD) in children by determining the sensitivity and negative predictive values of upper and lower endoscopic biopsies for children suspected of GI GVHD.Methods: Patients suspected of GI GVHD who received endoscopic evaluation within 100 days after stem cell trans-plantation and endoscopies between January 2012 and March 2014 in Seoul National University Children’s Hospital were included in our study.Results: Fifteen patients with a total of 20 endoscopic procedures were included in our study. Sensitivity at the esoph-agus, stomach, and duodenum were 22.2%, 30.0%, and 80.0%, respectively. Negative predictive values at the esophagus, stomach, and duodenum were 22.2%, 30.0%, and 60.0%, respectively. Overall sensitivity and negative predictive values of upper endoscopic biopsy for GVHD were 77.8% and 50.0%, respectively. Overall sensitivity and negative predictive values of lower endoscopic biopsy for GVHD were 88.9% and 66.7%, respectively.Conclusion: We recommend flexible sigmoidoscopy as a safe and accurate diagnostic tool for GVHD, similar to other studies reported previously. However, if there is no evidence of GVHD on sigmoidoscopy with high index of suspicion of GI bleeding, full colonoscopy and upper endoscopy should be considered.
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참고문헌 (22)
참고문헌 신청
Iqbal N / 2000 / Diagnosis of gastrointestinal graft-versus-host disease / Am J Gastroenterol 95:3034~3038
Couriel D / 2004 / Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management / Cancer 101:1936~1946
Ferrara JL / 1991 / Graft-versus-host disease / N Engl J Med 324:667~674
Wu D / 1998 / Persistent nausea and anorexia after marrow transplantation: a prospective study of 78 patients / Transplantation 66:1319~1324
Nevo S / 1999 / Acute bleeding after allogeneic bone marrow transplantation: association with graft versus host disease and effect on survival / Transplantation 67:681~689
Couriel D / 2004 / Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management / Cancer 101:1936~1946
Ferrara JL / 1991 / Graft-versus-host disease / N Engl J Med 324:667~674
Wu D / 1998 / Persistent nausea and anorexia after marrow transplantation: a prospective study of 78 patients / Transplantation 66:1319~1324
Nevo S / 1999 / Acute bleeding after allogeneic bone marrow transplantation: association with graft versus host disease and effect on survival / Transplantation 67:681~689
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