지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.9
- 수록면
- 267 - 274 (8page)
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초록· 키워드
오류제보하기
Toll-like receptors (TLRs) are one of the families of pattern recognition receptors (PRR) to recognize pathogenassociated molecular patterns (PAMPs). PAMPs stimulate TLRs to initiate specific immunoactivity. The activation of TLRs signaling leads to the expression of pro-inflammatory gene products such as cytokines and inducible nitric oxide synthase (iNOS). To evaluate the therapeutic potential of dehydrocostus lactone (DHL), which is a natural sesquiterpene lactone derived from various medicinal plants, iNOS expression induced by LPS (TLR4 agonist), MALP-2 (TLR2 and TLR6 agonist), or Poly[I:C] (TLR3 agonist) were examined. DHL suppressed the iNOS expression induced by LPS, MALP-2, or Poly[I:C]. DHL also inhibited nitrite production induced by LPS, MALP-2, or Poly[I:C]. These results suggest that DHL can modulate TLRs signaling pathways resulting in anti-inflammatory effect.
목차
서론
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (39)
참고문헌 신청
Akira S / 2004 / Toll-like receptor signalling / Nat Rev Immunol 4:499~511
Anderson KV / 1985 / Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product / Cell 42:791~798
Asea A / 2002 / Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4 / J Biol Chem 277:15028~15034
Butturini E / 2011 / Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation / PLoS One 6:e20174
Chauhan SD / 2003 / Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice / FASEB J 17:773~775
Anderson KV / 1985 / Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product / Cell 42:791~798
Asea A / 2002 / Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4 / J Biol Chem 277:15028~15034
Butturini E / 2011 / Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation / PLoS One 6:e20174
Chauhan SD / 2003 / Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice / FASEB J 17:773~775
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