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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.7 No.2
- 발행연도
- 2015.1
- 수록면
- 130 - 140 (11page)
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초록· 키워드
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Purpose: Asthma is a complex disease, with contributions from multiple genes, various genetic backgrounds, and environmental factors. Many human epidemiological studies have demonstrated that single nucleotide polymorphisms (SNPs) in Toll-like receptor (TLR) genes are inconsistently associated with asthma risk. Some have demonstrated differences concerning the study design and effect size, and conflicting results have been reported.
A meta-analysis is necessary to determine the magnitude of this association. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, a systematic search and meta-analysis of the literature was conducted to estimate the association of SNPs in TLR genes with asthma risk. We screened the medical literature based on the following keyword searches in MEDLINE and EMBASE databases: ‘TLR’, ‘polymorphism’, ‘asthma’, and their combinations. Results: Meta-analysis of eight studies on TLR4 Asp299Gly showed a marginal association of TLR4 with asthma risk (odds ratio [OR]=0.814 [95% confidence interval [CI], 0.652-1.016; P=0.069]) in the recessive model. TLR4 Thr399Ile was not associated with asthma risk under any genetic model. Meta-analysis of four studies on TLR2 Arg753Gln indicated that TLR2 might be significantly associated with asthma in the dominant and codominant models (P=0.029, P=0.030, and P=0.009, respectively). TLR9 -1237 was marginally associated with asthma risk (OR=0.408 [95% CI, 0.163-1.021; P=0.065]) in the codominant model. Analysis using the allele contrast model showed that the major TLR9 -1237 T allele tended to be a significant protective factor with OR=0.689 (95% CI, 0.471-1.007; P=0.055).
Conclusions: The results showed that TLR4 Asp299Gly, TLR2 Arg753Gln, and TLR9-1237 might contribute significantly to asthma susceptibility. Future genetic association studies would consolidate these findings.
목차
등록된 정보가 없습니다.
참고문헌 (80)
참고문헌 신청
Corrigan CJ / 1988 / T lymphocyte activation in acute severe asthma / Lancet 1:1129~1132
Devenny A / 2004 / Respiratory symptoms and atopy in children in Aberdeen: questionnaire studies of a defined school population repeated over 35 years / BMJ 329:489~490
Ho SM. / 2010 / Environmental epigenetics of asthma: an update / J Allergy Clin Immunol 126:453~465
Ober C / 2011 / The genetics of asthma and allergic disease: a 21st century perspective / Immunol Rev 242:10~30
이신화 / 2011 / The Search for Genetic Variants and Epigenetics Related to Asthma / Allergy, Asthma & Immunology Research 3(4):236~244
Devenny A / 2004 / Respiratory symptoms and atopy in children in Aberdeen: questionnaire studies of a defined school population repeated over 35 years / BMJ 329:489~490
Ho SM. / 2010 / Environmental epigenetics of asthma: an update / J Allergy Clin Immunol 126:453~465
Ober C / 2011 / The genetics of asthma and allergic disease: a 21st century perspective / Immunol Rev 242:10~30
이신화 / 2011 / The Search for Genetic Variants and Epigenetics Related to Asthma / Allergy, Asthma & Immunology Research 3(4):236~244
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