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Allergic disease such as atopic dermatitis, asthma and rhinitis is an immune disease characterized by the skin inflammation and the abnormal expression of cytokines including interleukin. It has been reported that the immune response is differently changed according to a kind of a chemical allergens or an inbred mouse strain. However, in preview studies, there have been no trials to elucidate an allergic response in the chronic diseases model. Thus, the aim of this study was to investigate whether a phthalic anhydride (PA) as chemical allergen would impact on the immonological factors of several disease model such as TG2576 (Alzheimer’s disease model) or NOD (type I diabetes disease model). To accomplish this, the 15% (w/v) PA solution was repeatedly spread on the ear’s dorsum of three types of animals including BALB/c, TG2576 and NOD mice and the ear thickness of them was measured by vernier calipers for 12 days. After treatment, the immune response-related factors were detected in the lymph node of three kinds of mice, respectively. The ear thickness indicating degree of skin inflammation was significantly increased in the TG2576 and NOD mice compared with BALB/c mice. Also, interleukin-4 in auricular lymph node was significantly changed in the disease model mice. These findings suggest that the PA solution as chemical allergen can induce the difference on skin inflammation and interleukin-4 expression as the allergic-related immunological factors among the BALB/c, TG2576, NOD mice.

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UCI(KEPA) : I410-ECN-0101-2009-510-014753504