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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 51 - 57 (7page)
이용수
초록· 키워드
오류제보하기
Based on 1 year-long randomized double-blind placebo-controlled clinical study at one of Korean reputed hospitals, the combined test material (Estromon<SUP>®</SUP>) of the new phytoestrogen FGF271 (the extract of the three mixed herbs), amino acid, vitamins and minerals has been significantly effective to improve such menopausal symptoms as vaginal dryness and hot flush, serum osteocalcin level and bone mineral density (BMD) of femoral bone. This in vitro research was done to find out the phytoestrogen effect of FGF271 while in vivo research was designed to investigate the sole effect of FGF271 by comparing with Estromon<SUP>®</SUP>. In result, cell proliferation and alkaline phosphatase (ALP) induction study of MCF-7, Ishikawa, and SaOS-2 cell shows that Cynanchum wilfordii, Phlomis umbrosa, Angelica gigas, and FGF271 have phytoestrogenic effect, respectively and FGF271 has higher phytoestrogenic effect than the individual herbal extract. In ovariectomized (OVX) animal experiment to investigate the sole effect of FGF271 by comparing it with Estromon<SUP>®</SUP>, the oral administration of 100 ㎎/㎏ of FGF271 per day for 12 weeks significantly increased BMD of femoral bone of rats compared to ovariectomised control group (P＜0.05) while the group of 100 ㎎/㎏ of Estromon<SUP>®</SUP> did not show significant difference statistically. In conclusion, it was revealed that the improvement of menopausal symptoms and BMD of femoral bone in the clinical study was caused solely by the phytoestrogenic effect of FGF271 in the Estromon<SUP>®</SUP>.
목차
재료 및 방법
결과 및 고찰
Acknowledgment
References
참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - Clarke, A.P / 1992 / Targeted estrogen/progestogen replacement therapy for osteoporosis: calculation of health care cost savings / Osteoporosis Int 2 : 195 ~ 200
2. [학술지(정기간행물)] - Cummings, S.R / 1990 / The future of hip fractures in the United States: numbers, costs and potential effects of postmenopausal estrogen / Clin. Orthoped. Related 252 : 163 ~ 166
3. [학술지(정기간행물)] - Elfituri, A / 2005 / Two hormone replacement therapy (HRT) regimens for middleeastern postmenopausal women / Maturitas 52 (1) : 52 ~ 59
4. [학술지(정기간행물)] - Holinka, C.F / 1986 / Effects of estradiol on proliferation of endometrial adrenalcarcinoma cells (Ishikawa line) / J. Steroid Biochem 25 : 781 ~ 786
5. [학술지(정기간행물)] - Fandti, P / 1998 / The phytoestrogen genistein reduces bone loss in shrot-ern ovariectomized rats / Osteroporos Int 8 (3) : 274 ~ 281
2. [학술지(정기간행물)] - Cummings, S.R / 1990 / The future of hip fractures in the United States: numbers, costs and potential effects of postmenopausal estrogen / Clin. Orthoped. Related 252 : 163 ~ 166
3. [학술지(정기간행물)] - Elfituri, A / 2005 / Two hormone replacement therapy (HRT) regimens for middleeastern postmenopausal women / Maturitas 52 (1) : 52 ~ 59
4. [학술지(정기간행물)] - Holinka, C.F / 1986 / Effects of estradiol on proliferation of endometrial adrenalcarcinoma cells (Ishikawa line) / J. Steroid Biochem 25 : 781 ~ 786
5. [학술지(정기간행물)] - Fandti, P / 1998 / The phytoestrogen genistein reduces bone loss in shrot-ern ovariectomized rats / Osteroporos Int 8 (3) : 274 ~ 281
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UCI(KEPA) : I410-ECN-0101-2009-510-014753544