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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 669 - 674 (6page)
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Foot cartilage of pig has been used as a traditional food material for enhancement of health. To investigate various effects of foot cartilage of pig, Glycosaminoglycans (GAGs) of porcine cartilage were isolated through anion exchange chromatography (DOWEX macroporous resin) and composition of GAGs was analyzed by high pressure liquid chromatography (HPLC). From the anion exchange chromatography, we obtained two types of GAGs, P-3 and P-16 that were eluted by 3% and 16% sodium chloride concentration respectively. The anticoagulant activity of the GAGs isolate from foot cartilage was investigated by activated partial thromboplastin times (APTT) assay. P-16, but not P-3, showed a prolonged activity of the clotting time, and its anticoagulant activity was dose-dependent. In immunomodulating activity analysis, P-3 as well as P-16 markedly suppressed the growth of murine splenocytes stimulated by concanavalin-A (ConA) or lipopoly-saccharide (LPS). Interestingly, both of P-3 and P-16 significantly enhanced the growth of normal peritoneal macrophages, but only P-3, but not P-16, had a weak effect on the growth of LPS-treated macrophages. However, these two porcine GAGs did not show any significant inhibition of cytokine production from mitogen-stimulated splenocytes and macrophages. An chromatographic assay using SAX-HPLC column revealed that the main fraction of P-16 was Di-4S. These results suggest that GAGs of porcine cartilage possess biological activities such as anticoagulant and immunomodulating activity.
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감사의 글
참고문헌
참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - Homma, R. / 2005 / Modulation of blood coagulation and fibrinolysis by polyamines in the presence of glycosaminoglycans / Int. J. Biochem. Cell Biol 37 : 1911 ~ 1920
2. [학술지(정기간행물)] - Jari, P. / 1999 / Biomechanical and structural characteristics of canine femoral and tibial cartilage / J. Biomed. Mater. Res 48 : 99 ~ 107
3. [단행본] - Kempson, G.E. / 1980 / The mechanical properties of articular cartilage. In:The joints and synovial fluid. Vol. Ⅱ / Academic Press : 177 ~ 238
4. [학술지(정기간행물)] - Lee, H.J. / 1999 / Inhibitory activities of sea weeds on prolyl endopeptidase, tyrosinase and coagulation / Kor. J. Pharmacogn 30 : 231 ~ 237
5. [학술지(정기간행물)] - Lee, K.B. / 1998 / Isolation and identification of chondroitin sulfates from the mud snail / Arch. Pharm. Res 21 : 555 ~ 558
2. [학술지(정기간행물)] - Jari, P. / 1999 / Biomechanical and structural characteristics of canine femoral and tibial cartilage / J. Biomed. Mater. Res 48 : 99 ~ 107
3. [단행본] - Kempson, G.E. / 1980 / The mechanical properties of articular cartilage. In:The joints and synovial fluid. Vol. Ⅱ / Academic Press : 177 ~ 238
4. [학술지(정기간행물)] - Lee, H.J. / 1999 / Inhibitory activities of sea weeds on prolyl endopeptidase, tyrosinase and coagulation / Kor. J. Pharmacogn 30 : 231 ~ 237
5. [학술지(정기간행물)] - Lee, K.B. / 1998 / Isolation and identification of chondroitin sulfates from the mud snail / Arch. Pharm. Res 21 : 555 ~ 558
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