장생도라지 (Platycodon grandiflorum)의 항산화 활성 평가

김충현; 정봉용; 정선기; 이철호; 이현선; 김봉희; 김상겸

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자료유형: 학술저널

저자정보: 김충현 (충남대학교) 정봉용 (충남대학교) 정선기 (충남대학교) 이철호 (한국생명공학연구원) 이현선 (한국생명공학연구원) 김봉희 (충남대학교) 김상겸 (충남대학교)

저널정보: 환경독성보건학회 Environmental Analysis Health and Toxicology 환경독성학회지 제25권 제1호

발행연도: 2010.3

수록면: 85 - 94 (10page)

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Platycodon grandiflorum, Doraji as Korean name, is one of the most widely used traditional oriental medicine for bronchial diseases and also used as a folk remedy for geriatric diseases and inflammatory diseases. In recent studies, it has been reported that some effect of P. grandijlorum is derived from its antioxidant activity, although there is still a lack of evidence to establish its oxy-radical scavenging activity. In this study, total oxy-radical scavenging capacity (TOSC) assay was used to evaluate antioxidant activity of total extracts (T-PG), polysaccharide fraction (Po-PG), and saponin fraction (Sa-PG) isolated from P. grandiflorum against peroxyl radicals and peroxynitrites. And MTT assay was taken to assess cyto-protective effects of T-PG, Po-PG and Sa-PG in H4IIE cells treated with hydrogen peroxide and tert-butylhydroperoxide. In the TOSC assay, Sa-PG showed strong oxy-radical scavenging capacity compared with T-PG and Po-PG. In cell-based assay, T-PG and Po-PG protected cells from oxidative stress, but Sa-PG did not protect cells because of cytotoxicity of Sa-PG. These results suggest that the saponin components of P. grandiflorum have relatively strong antioxidant capacity and cytotoxicity in rat hepatoma cells.

#Platycodon grandiflorum #TOSC assay #cytotoxicity #oxidative stress #antioxidant capacity

참고문헌 (16)

참고문헌 신청

1. [학술지(정기간행물)] - Chandra J / 2000 / Triggering and modulation of apoptosis by oxidative stress / Free Radic Biol Med 29 (3) : 323 ~ 333

2. [학술지(정기간행물)] - Collins AR / 1999 / Oxidative DNA damage, antioxidants, and cancer / Bioessays 21 (3) : 238 ~ 246

3. [학술지(정기간행물)] - Dotan Y / 2004 / Lipid peroxidation cannot be used as a universal criterion of oxidative stress / Prog Lipid Res 43 (3) : 200 ~ 227

4. [학술지(정기간행물)] - Gupte SA / 2008 / Glucose-6-phosphate dehydrogenase: a novel therapeutic target in cardiovascular diseases / Curr Opin Investig Drugs 9 (9) : 993 ~ 1000

5. [학술지(정기간행물)] - Halliwell B / 1996 / Antioxidants in human health and disease / Annu Rev Nutr 16 : 33 ~ 50

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