지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 25 - 29 (5page)
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초록· 키워드
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The cytochrome P450 (P450, CYP) are the superfamily of heme-containing monooxygenase enzymes, found throughout all nature including mammals, plants, and microorganisms. Mammalian P450 enzymes are involved in oxidative metabolism of a wide range of endo- and exogenous chemicals. Especially P450s involved in drug metabolisms are important for drug efficacy and polymorphisms of P450s in individuals reflect differences of drug responses between people. To study the functional differences of CYP2A6, CYP2D6, and CYP4A11 variants, we cloned the four CYP2A6, three CYP2D6, and three CYP4A11 variants, which were found in Korean populations, in mammalian expression vector pcDNA by PCR and examined their expressions in COS-7 mammalian cells using immunoblots using P450 specific polyclonal antibodies. Three of four CYP2A6, two of three CYP4A11, and two of three CYP2D6 variants showed expressions in COS-7 cells but the relative levels of expressions are remarkably different in those of each variants. Our findings may help to study and explain the differences between functions of CYP variants and drug responses in Korean populations.
목차
INTRODUCTION
MATERIAL AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (23)
참고문헌 신청
Bandiera, S. / 2005 / Proteasomal degradation of human CYP1B1:effect of the Asn453Ser polymorphism on the post-translationalregulation of CYP1B1 expression / Mol. Pharmacol 67:435~443
Cho, B.H. / 2005 / Highly polymorphic human CYP4A11 gene / JOURNAL OF HUMAN GENETICS 50:259~263
Daly,A.K / 1995 / Molecular basis of polymorphic drug metabolism / J. Mol. Med 73:539~553
Danielson,P.B / 2002 / The cytochrome P450 superfamily: biochemistry,evolution and drug metabolism in humans / Curr.Drug. Metab 3:561~597
Di, Y.M. / 2009 / . Structure,function, regulation and polymorphism of human cytochromeP450 2A6 / Curr. Drug. Metab 10:754~780
Cho, B.H. / 2005 / Highly polymorphic human CYP4A11 gene / JOURNAL OF HUMAN GENETICS 50:259~263
Daly,A.K / 1995 / Molecular basis of polymorphic drug metabolism / J. Mol. Med 73:539~553
Danielson,P.B / 2002 / The cytochrome P450 superfamily: biochemistry,evolution and drug metabolism in humans / Curr.Drug. Metab 3:561~597
Di, Y.M. / 2009 / . Structure,function, regulation and polymorphism of human cytochromeP450 2A6 / Curr. Drug. Metab 10:754~780
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UCI(KEPA) : I410-ECN-0101-2012-513-004366302