지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.8
- 수록면
- 114 - 120 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: The gastric cancer is a common malignancy worldwide. Developing a screening test for gastric cancer is important because early-stage gastric cancer has a good prognosis. So, we investigated the effect of the CYP2E1 and CYP2C19 polymorphisms on the susceptibility for gastric cancer.
Methods: We studied 92 patients who were diagnosed with gastric cancer at Hospital and 80 patients who were admitted during the same period. Polymerase chain reaction (PCR) was performed for the 96-bp insertion polymorphism of CYP2E1 and the poor metabolizer of CYP2C19. The expressions of CYP2E1 and CYP2C19 in case and control groups were compared by Student’s t-test and logistic regression analysis.
Results: The distribution of the CYP2E1 96-bp insertion polymorphism was 61 (66.3%), 28 (30.4%) and 3 (3.3%) for insert 0, insert 1 and insert 2 in the study group, respectively, and 61 (76.3%), 18 (22.5%) and 1 (1.3%) in control group, respectively. The distribution of the CYP2C19 poor metabolizer was 12 (13.0%) and 5 (5.4%) for CYP2C19<SUP>*</SUP>2/<SUP>*</SUP>2 and CYP2C19<SUP>*</SUP>2/<SUP>*</SUP>3 in the study group, respectively, and 3 (3.7%), 1 (1.3%) and 7 (8.8%) for CYP2C19<SUP>*</SUP>2/<SUP>*</SUP>2, CYP2C19<SUP>*</SUP>3/<SUP>*</SUP>3 and CYP2C19<SUP>*</SUP>2/<SUP>*</SUP>3 in control group, respectively. The ORs for CYP polymorphisms on stomach cancer were 1.2 (95% CI: 0.8∼3.2) in the CYP2E1 96-bp insert group and 1.4 (95% CI 0.6∼3.2) in the CYP2C19 PM. For the patients younger than 50 years, the OR of the CYP2C19 poor metabolizer for stomach cancer was much higher than, but there was the limitation that the age and gender distribution in the 2 groups did not match (P=0.004).
Conclusion: We noted that there was no significant correlation between the CYP2E1 and CYP2C19 polymorphisms and the gastric cancer group. Yet there was a tendency for the higher incidence of CYP2E1 and CYP2C19 polymorphisms in the gastric cancer group. Further well designed studies will be needed to conclude the effects of CYP2E1 and CYP2C19 polymorphisms on stomach cancer.
Methods: We studied 92 patients who were diagnosed with gastric cancer at Hospital and 80 patients who were admitted during the same period. Polymerase chain reaction (PCR) was performed for the 96-bp insertion polymorphism of CYP2E1 and the poor metabolizer of CYP2C19. The expressions of CYP2E1 and CYP2C19 in case and control groups were compared by Student’s t-test and logistic regression analysis.
Results: The distribution of the CYP2E1 96-bp insertion polymorphism was 61 (66.3%), 28 (30.4%) and 3 (3.3%) for insert 0, insert 1 and insert 2 in the study group, respectively, and 61 (76.3%), 18 (22.5%) and 1 (1.3%) in control group, respectively. The distribution of the CYP2C19 poor metabolizer was 12 (13.0%) and 5 (5.4%) for CYP2C19<SUP>*</SUP>2/<SUP>*</SUP>2 and CYP2C19<SUP>*</SUP>2/<SUP>*</SUP>3 in the study group, respectively, and 3 (3.7%), 1 (1.3%) and 7 (8.8%) for CYP2C19<SUP>*</SUP>2/<SUP>*</SUP>2, CYP2C19<SUP>*</SUP>3/<SUP>*</SUP>3 and CYP2C19<SUP>*</SUP>2/<SUP>*</SUP>3 in control group, respectively. The ORs for CYP polymorphisms on stomach cancer were 1.2 (95% CI: 0.8∼3.2) in the CYP2E1 96-bp insert group and 1.4 (95% CI 0.6∼3.2) in the CYP2C19 PM. For the patients younger than 50 years, the OR of the CYP2C19 poor metabolizer for stomach cancer was much higher than, but there was the limitation that the age and gender distribution in the 2 groups did not match (P=0.004).
Conclusion: We noted that there was no significant correlation between the CYP2E1 and CYP2C19 polymorphisms and the gastric cancer group. Yet there was a tendency for the higher incidence of CYP2E1 and CYP2C19 polymorphisms in the gastric cancer group. Further well designed studies will be needed to conclude the effects of CYP2E1 and CYP2C19 polymorphisms on stomach cancer.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [단행본] - Beauchamp RD / 2004 / Sabiston Textbook of Surgery. 17th ed / WB Saunders
2. [단행본] - Kim JP / 2002 / The clinicopathologic prognostic factor of gastric cancer, In Gastric Cancer. 1st ed / Medrang : 184 ~ 195
3. [학술지(정기간행물)] - Ohkubo Y / 2006 / Novel mutations in the cytochrome P450 2C19 gene: a pitfall of the PCR-RFLP method for identifying a common mutation / J Hum Genet 51 : 118 ~ 123
4. [학술지(정기간행물)] - Lee HJ / 2002 / Gastric cancer in Korea / Gastric Cancer 5 : 177 ~ 182
5. [학술지(정기간행물)] - Pelayo C / 2004 / The future of gastric cancer prevention / Gastric Cancer 7 : 9 ~ 16
2. [단행본] - Kim JP / 2002 / The clinicopathologic prognostic factor of gastric cancer, In Gastric Cancer. 1st ed / Medrang : 184 ~ 195
3. [학술지(정기간행물)] - Ohkubo Y / 2006 / Novel mutations in the cytochrome P450 2C19 gene: a pitfall of the PCR-RFLP method for identifying a common mutation / J Hum Genet 51 : 118 ~ 123
4. [학술지(정기간행물)] - Lee HJ / 2002 / Gastric cancer in Korea / Gastric Cancer 5 : 177 ~ 182
5. [학술지(정기간행물)] - Pelayo C / 2004 / The future of gastric cancer prevention / Gastric Cancer 7 : 9 ~ 16
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
CYP2E15B, CYP2E16, CYP2E17B, CYP2E12, and CYP2E13 Allele Frequencies in Iranian Populations
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Effects of CYP1A2$^*$1C and CYP1A2$^*$1F Genotypes on the Activity and Inducibility of CYP1A2 Determined by Urinary Caffeine Metabolite Ratio in Koreans
Molecular & cellular toxicology
2007 .01
-
한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰
생물정신의학
2000 .01
-
약물대사효소 CYP2C19, CYP2D6의 다형성과 사상체질의 관련성 연구
대한한의학회지
2007 .03
-
CYP2C19 Polymorphism in Korean Patients on Warfarin Therapy
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
Expression of CYP2A6, CYP2D6 and CYP4A11 Polymorphisms in COS7 Mammalian Cell Line
Toxicological Research
2011 .03
-
Effects of Korean traditional herbal formula for common cold on the activities of human CYP450 isozymes
대한한의학회지
2014 .06
-
Association of CYP2C19*2 and *3 Genetic Variants with Essential Hypertension in Koreans
Yonsei Medical Journal
2012 .01
-
CYP2E1 Genetic Polymorphisms and Breast Cancer
대한외과학회 학술대회 초록집
2001 .11
-
Four Polymorphisms in the Cytochrome P450 1A2 (CYP1A2) Gene and Lung Cancer Risk: a Meta-analysis
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
한약재의 Cytochrome P450 결합관련 안전성에 관한 연구
대한한방내과학회지
2013 .01
-
RNA Expression of Cytochrome P450 in Mexican Women with Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
The Genetic Analysis of CYP2C9 Polymorphism in a Korean Population
대한임상약리학회 학술대회
1998 .01
-
Association of CYP2C19 Polymorphisms with Survival of Breast Cancer Patients Using Tamoxifen: Results of a Meta-analysis
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Relationship between CYP17 and CYP11${\alpha}$, and PCOS in Korean Population
대한생식의학회 학술대회
2003 .01
-
암브록솔과 세티리진의 Cytochrome P450 저해 활성 평가
약학회지
2013 .01
-
Meta-analysis of Association Studies of CYP1A1 Genetic Polymorphisms with Digestive Tract Cancers Susceptibility in Chinese
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Preferential Induction of CYP1A1 over CYP1B1 in Human Breast Cancer MCF-7 Cells after Exposure to Berberine
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
벤젠 대사에 있어서 CYP2E1 유전자다형성의 영향
Toxicological Research
2002 .12
이 논문의 저자 정보
이 논문과 함께 이용한 논문
주의력결핍 과잉행동장애 아동에서 α-2A 아드레날린 수용체 유전자의 MspI 유전자 다형성에 따른 메칠페니데이트 치료 전후 뇌관류 비교
박수빈
,
배정훈
,
김재원
외 8명
소아청소년정신의학
2013
.03
한국인 대장암 환자의 종양조직에서 APC 유전자변이
조상혁
,
허정욱
,
김영진
외 2명
Annals of Surgical Treatment and Research
2009
.03
약물대사효소 CYP2C19, CYP2D6의 다형성과 사상체질의 관련성 연구
이상규
,
김현주
,
박혜정
외 6명
대한한의학회지
2007
.03
새로운 항우울제들의 약물 상호작용
이광헌
생물치료정신의학
2000
.06
Expression of CYP2A6, CYP2D6 and CYP4A11 Polymorphisms in COS7 Mammalian Cell Line
Hye Ja Lee
,
Mi Kyung Pa
,
k
외 9명
Toxicological Research
2011
.03
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-514-002673256