지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.16 No.2
- 발행연도
- 2011.6
- 수록면
- 95 - 103 (9page)
이용수
초록· 키워드
오류제보하기
This study was performed to investigate the antioxidant mechanism of tomato wine with varying lycopene content in rats fed a high fat diet (HFD). Male Sprague-Dawley rats were randomly divided into five groups (n=10 per group) and fed an HFD (35% of total energy from fat) plus ethanol (7.2% of total energy from alcohol), tomato wine with varying lycopene content (0.425 ㎎%, 1.140 ㎎% or 2.045 ㎎% lycopene) or an isocaloric control diet for 6 weeks. Mice fed HFD plus ethanol significantly increased erythrocyte hydrogen peroxide and thiobarbituric acid reactive substances (TBARS) levels with increases in activities of erythrocyte antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) compared to pair-fed rats. Supplementation of tomato wine with varying lycopene content decreased ethanol-mediated increases of erythrocyte lipid peroxidation and antioxidant enzyme activities in HFD-fed rats, and tomato wine with higher lycopene appeared to be more effective. Tomato wine also dose-dependently lowered TBARS levels with decreased pro-oxidant enzyme, xanthine oxidase (XOD) activity in plasma of HFD-fed rats. In contrast to erythrocytes, the inhibitory effects of tomato wine on hepatic lipid peroxidation were linked to increased hepatic antioxidant enzymes (SOD and CAT) and alcohol metabolizing enzyme (alcohol dehydrogenase and aldehyde dehydrogenase) activities. There were no significant differences in hepatic XOD and cytochrome P450-2E1 activities among the groups. Together, our data suggest that tomato wine fortified with lycopene has the potential to protect against ethanol-induced oxidative stress via regulation of antioxidant or pro-oxidant enzymes and alcohol metabolizing enzyme activities in plasma, erythrocyte and liver.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ABBREVIATIONS
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (58)
참고문헌 신청
Jeung Hee An / 2009 / Proteomic Analysis of the Protective Effects of Platycodi Radix in Liver of Chronically Alcoholic Rats / Journal of Medicinal Food 12(6):1190~1198
Lieber CS / 1991 / Hepatic metabolic and toxic effect of ethanol / Alcohol Clin Exp Res 5:573~592
Liber CS / 1994 / Alcohol and the liver / Hepatology 106:1085~1105
Demoria I / 2006 / Combined effects of high-fat diet and ethanol induce oxidative stress in rat liver / Alcohol 40:185~191
Renaud S / 1992 / Wine, alcohol, platelets, and the French paradox for coronary heart disease / Lancet 339:1523~1526
Lieber CS / 1991 / Hepatic metabolic and toxic effect of ethanol / Alcohol Clin Exp Res 5:573~592
Liber CS / 1994 / Alcohol and the liver / Hepatology 106:1085~1105
Demoria I / 2006 / Combined effects of high-fat diet and ethanol induce oxidative stress in rat liver / Alcohol 40:185~191
Renaud S / 1992 / Wine, alcohol, platelets, and the French paradox for coronary heart disease / Lancet 339:1523~1526
이 논문의 저자 정보
이 논문과 함께 이용한 논문
황금추출물이 고지방 식이를 급여한 흰쥐의 지질대사 및 항산화방어계에 미치는 영향
윤혜진
,
박영숙
한국식품영양과학회지
2010
.02
토마토 과실주의 알코올발효조건에 따른 이화학적 특성 변화
김옥미
,
장세영
,
우승미
외 3명
한국식품영양과학회지
2010
.10
비타민 C 보충과 요가가 중년여성의 혈청 지질과산화물가 개선에 미치는 영향
강영수
,
이상호
,
백영호
한국식품영양과학회지
2009
.01
자두와인의 섭취가 흰쥐의 지질대사 및 지질과산화에 미치는 영향
윤옥현
,
강병태
,
이재우
외 1명
한국식품영양과학회지
2008
.04
수박 시트룰린 고함량 유전자원 선발
이우문
,
이희주
,
양은영
외 6명
한국원예학회 학술발표요지
2013
.10
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-511-000539534