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논문 기본 정보

자료유형
학술저널
저자정보
김희정 (이화여자대학교) 김혜숙 (이화여자대학교) 김기남 (이화여자대학교) 김꽃핀 (이화여자대학교) 손정인 (서울아산병원) 김성윤 (서울아산병원) 장남수 (이화여자대학교)
저널정보
한국영양학회 한국영양학회지 한국영양학회지 제44권 제6호
발행연도
2011.12
수록면
498 - 506 (9page)

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This study examined the relationship among plasma homocysteine, folate, and vitamin B<SUB>12</SUB> levels and neurocognitive function in 118 community-dwelling elderly subjects (mean age, 75.1 ± 6.7 years). The Mini-Mental State Examination (MMSE-KC) was used to screen and assess neurocognitive function in the participants. Dietary intake data including the use of dietary supplements were obtained using the 24-hour recall method by well-trained interviewers. Plasma folate and vitamin B12 concentrations were analyzed by radioimmunoassay, and homocysteine was assessed by a high performance liquid chromatography-fluorescence method. The proportions of participants with suboptimal levels of plasma folate (< 3 ng/mL), vitamin B<SUB>12</SUB> (< 221 pmol/mL), and homocysteine ( > 15 μmol/L) were 16.1%, 5.9%, and 21.2%, respectively. A multiple regression analysis showed that plasma homocysteine was negatively associated with plasma folate and vitamin B<SUB>12</SUB> levels. The MMSE-KC test scores were significantl y associated with plasma homocysteine and folate, but not with vitamin B<SUB>12</SUB>, after adjusting for age, gender, body mass index, living with spouse, education, current smoking, energy intake, and chronic diseases such as hypertension, diabetes, thyroid disease, dyslipidemia, stroke, and cardiovascular disease. A general linear model adjusted for covariates revealed that MMSE-KC test scores increased from the lowest to the highest quartiles of vitamin B<SUB>1</SUB>, vitamin B<SUB>2</SUB>, vitamin B<SUB>6</SUB>, vitamin B<SUB>12</SUB>, and vitamin C intake (p for trend = 0.012, 0.039, 0.014, 0.046, 0.026, respectively). These results indicate that the problem of folate inadequacy and hyperhomocysteinemia are highly prevalent among community-dwelling elderly people and that dietary intake of the B vitamins and vitamin C is positively associated with cognitive function scores. (Korean J Nutr 2011; 44(6): 498 ~ 506)

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UCI(KEPA) : I410-ECN-0101-2013-594-001198938