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논문 기본 정보

자료유형
학술저널
저자정보
Min Hwa Lee (Chung-Ang University) Bog-Hieu Lee (Chung-Ang University) Ji-Youn Jung (Kongju National University) Doo-Sung Cheon Kyung-Tack Kim Changsun Choi (Chung-Ang University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.35 No.4
발행연도
2011.12
수록면
429 - 435 (7page)

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초록· 키워드

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Korean red ginseng has been studied various biological activities such as immune, anti-oxidative, anti-microbial, and anticancer activities but antiviral mechanism needs further studies. In this study, we aimed to examine the antiviral effects of Korea red ginseng extract and ginsenosides on norovirus surrogate, including murine norovirus (MNV) and feline calicivirus (FCV). We evaluated the pre-, co-, and post-treatment effects of Korean red ginseng (KRG), ginsenosides Rb<SUB>1</SUB>, and Rg<SUB>1</SUB>. To measure the antiviral effect and cytotoxicity of KRG extract, and ginsenosides Rb<SUB>1</SUB>, and Rg<SUB>1</SUB>, we treated Crandell-Reese Feline Kidney for FCY or RAW264.7 cells for MNV with concentrations of 0, 5, 6.7, 10,20 ug/ml, total saponin. There was cytotoxic effect in the highest concentration 20 ug/mL of KRG extract so this concentration was excluded in this study. The FCV titer was significantly reduced to 0.23-0.83 log<SUB>10</SUB> 50% tissue culture infectious dose (TCID<SUB>50</SUB>)/mL in groups pre-treated with red ginseng extract or ginsenosides. The titer of MNY was significantly reduced to 0.37-1.48 log<SUB>10</SUB> TCID<SUB>50</SUB>mL in groups pre-treated with red ginseng extract or ginsenosides. However, there was no observed antiviral effect in groups co-treated or post-treated with KRG and its constituents. Our data suggest that KRG extract has an antiviral effect against norovirus surrogates. The antiviral mechanisms of KRG and ginsenosides should be addressed in future studies.

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2013-524-001212599