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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.4
- 수록면
- 85 - 92 (8page)
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초록· 키워드
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Objective : The purpose of this study was to investigate the anti-cancer effects of Sophorae Radix and the effects of 5-Fluorouracil (5-FU) in human gastric adenocarcinoma cells (AGS).
Method : We used human gastric adenocarcinoma cell line, AGS cells. We examined cell death by MTT assay and caspase 3 assay with Sophorae Radix. To examine the inhibitory effects of Sophorae Radix, cell cycle (sub G1) analysis was done the AGS cells after three days with Sophorae Radix. The reversibility of Sophorae Radix was examined on one day to five days treatment with 100 ㎍/ml Sophorae Radix.
Result : Sophorae Radix inhibited the growth of AGS cells in a dose-dependent fashion. Also we showed that Sophorae Radix induced apoptosis in AGS cells by MTT assay, caspase 3 assay and sub-G1 analysis. Sophorae Radix combined with 5-FU markedly inhibited the growth of AGS cells compared to Sophorae Radix or 5-FU alone. After 3 days treatment of AGS cells with Sophorae Radix, the fraction of cells in sub-G1 phase was much higher than that of the control group.
Conclusion : Our findings provide insight into unraveling the effects of Sophorae Radix in human gastric adenocarcinoma cells and developing therapeutic agents against gastric cancer.
Method : We used human gastric adenocarcinoma cell line, AGS cells. We examined cell death by MTT assay and caspase 3 assay with Sophorae Radix. To examine the inhibitory effects of Sophorae Radix, cell cycle (sub G1) analysis was done the AGS cells after three days with Sophorae Radix. The reversibility of Sophorae Radix was examined on one day to five days treatment with 100 ㎍/ml Sophorae Radix.
Result : Sophorae Radix inhibited the growth of AGS cells in a dose-dependent fashion. Also we showed that Sophorae Radix induced apoptosis in AGS cells by MTT assay, caspase 3 assay and sub-G1 analysis. Sophorae Radix combined with 5-FU markedly inhibited the growth of AGS cells compared to Sophorae Radix or 5-FU alone. After 3 days treatment of AGS cells with Sophorae Radix, the fraction of cells in sub-G1 phase was much higher than that of the control group.
Conclusion : Our findings provide insight into unraveling the effects of Sophorae Radix in human gastric adenocarcinoma cells and developing therapeutic agents against gastric cancer.
목차
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
참고문헌
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Van Cutsem E / 2004 / The treatment of advanced gastric cancer: new findings on the activity of the taxanes / Oncologist (2) : 9 ~ 15
2. [학술지(정기간행물)] - Lin J / 2004 / Molecular biology of upper gastrointestinal malignancies / Semin Oncol 31 (4) : 476 ~ 486
3. [학술지(정기간행물)] - 김준한 / 2003 / 홍화의 부위별 화학성분과 DPPH Radical 소거 활성 / 한국식품영양과학회지 32 (5) : 733 ~ 738
4. [단행본] - 한약조제사고시연구회 / 1996 / 한약재감별능력평가 / 학문사
5. [단행본] - 신민교 / 1986 / 임상본초학 / 남산당 : 314 ~ 316
2. [학술지(정기간행물)] - Lin J / 2004 / Molecular biology of upper gastrointestinal malignancies / Semin Oncol 31 (4) : 476 ~ 486
3. [학술지(정기간행물)] - 김준한 / 2003 / 홍화의 부위별 화학성분과 DPPH Radical 소거 활성 / 한국식품영양과학회지 32 (5) : 733 ~ 738
4. [단행본] - 한약조제사고시연구회 / 1996 / 한약재감별능력평가 / 학문사
5. [단행본] - 신민교 / 1986 / 임상본초학 / 남산당 : 314 ~ 316
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