지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 533 - 542 (10page)
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초록· 키워드
오류제보하기
Purpose: Although varicose veins are very common in adults, the mechanism of the disease has not been established. Degradation of the extracellular matrix is regulated by various matrix metallopreteinases (MMPs) and their inhibitors tissue inhibitor of metallaproteinase (TIMPs). This study was performed to analyse the relationship between venous wall degeneration and expression of these matrix proteinases.
Methods: Twelve great saphenous vein (GSV) segments from 7 patients without varicose veins (control) and 86 GSV segments from 18 patients (22 limbs) with varicose veins (C<SUB>2,4,5</SUB>E<SUB>P</SUB>A<SUB>S</SUB>P<SUB>R</SUB>) were used for this study. Light microscopic examination was used in the evaluation of vein wall degeneration, immunohistochemistry and Western blotting for the expression of MMPs (MMP-1, MMP-2, MMP-9 and MMP-13) and TIMPs (TIMP-1 and TIMP-2), and zymography for gelatinolytic activity of MMP-2 and MMP-9 were performed.
Results: MMP-9 was more strongly expressed in the vein wall of both control and patient groups, especially in the endothelial cells and medial muscle layers and TIMP-2 followed. The expression of MMP-9 was closely related to the degree of venous wall degeneration. Activated MMP-2 and MMP-9 were observed in both groups and expressed more in the proximal GSV of the patients. In the Western blotting, the expression of MMP-9 and TIMP-1 were significantly higher than other MMPs and TIMP-2 in the patients with varicose veins.
Conclusion: MMP-9 is much more expressed in the wall of degenerative veins. This matrix-degrading enzyme may play an important role in the degeneration of venous wall followed by its remodeling.
Methods: Twelve great saphenous vein (GSV) segments from 7 patients without varicose veins (control) and 86 GSV segments from 18 patients (22 limbs) with varicose veins (C<SUB>2,4,5</SUB>E<SUB>P</SUB>A<SUB>S</SUB>P<SUB>R</SUB>) were used for this study. Light microscopic examination was used in the evaluation of vein wall degeneration, immunohistochemistry and Western blotting for the expression of MMPs (MMP-1, MMP-2, MMP-9 and MMP-13) and TIMPs (TIMP-1 and TIMP-2), and zymography for gelatinolytic activity of MMP-2 and MMP-9 were performed.
Results: MMP-9 was more strongly expressed in the vein wall of both control and patient groups, especially in the endothelial cells and medial muscle layers and TIMP-2 followed. The expression of MMP-9 was closely related to the degree of venous wall degeneration. Activated MMP-2 and MMP-9 were observed in both groups and expressed more in the proximal GSV of the patients. In the Western blotting, the expression of MMP-9 and TIMP-1 were significantly higher than other MMPs and TIMP-2 in the patients with varicose veins.
Conclusion: MMP-9 is much more expressed in the wall of degenerative veins. This matrix-degrading enzyme may play an important role in the degeneration of venous wall followed by its remodeling.
목차
서론
방법
결과
고찰
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (27)
참고문헌 신청
1. [단행본] - Rose SS / 1999 / Anatomic observation on causes of varicose veins. In Varicose Veins and Telangiectasias: Diagnosis and Treatment. 2nd ed. / Quality Medical Publishing : 12 ~ 41
2. [학술지(정기간행물)] - Elsharawy MA / 2007 / Role of saphenous vein wall in the pathogenesis of primary varicose veins / Interact Cardiovasc Thorac Surg 6 : 219 ~ 224
3. [학술지(정기간행물)] - Golledge J / 2003 / Pathogenesis of varicose veins / Eur J Vasc Endovasc Surg 25 : 319 ~ 324
4. [학술지(정기간행물)] - Raffetto JD / 2008 / Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease / Biochem Pharmacol 75 : 346 ~ 359
5. [학술지(정기간행물)] - Parra JR / 1998 / Tissue inhibitor of metalloproteinase-1 is increased in the saphenofemoral junction of patients with varices in the leg / J Vasc Surg 28 : 669 ~ 675
2. [학술지(정기간행물)] - Elsharawy MA / 2007 / Role of saphenous vein wall in the pathogenesis of primary varicose veins / Interact Cardiovasc Thorac Surg 6 : 219 ~ 224
3. [학술지(정기간행물)] - Golledge J / 2003 / Pathogenesis of varicose veins / Eur J Vasc Endovasc Surg 25 : 319 ~ 324
4. [학술지(정기간행물)] - Raffetto JD / 2008 / Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease / Biochem Pharmacol 75 : 346 ~ 359
5. [학술지(정기간행물)] - Parra JR / 1998 / Tissue inhibitor of metalloproteinase-1 is increased in the saphenofemoral junction of patients with varices in the leg / J Vasc Surg 28 : 669 ~ 675
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