지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.11
- 수록면
- 344 - 352 (9page)
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초록· 키워드
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Purpose: The expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs) caused by hydrostatic pressure stress is important in the development of varicose veins (VVs). This study was performed to analyse the expression of various MMPs and TIMPs according to the hydrostatic stress and the anatomical level of human great saphenous vein (GSV).
Methods: Forty-nine vein samples were obtained from 10 patients with VVs (control group), and 34 samples from 7 VV patients after 1-hour hydrostatic stress just before surgery (stress group) at each anatomical site (proximal, Hunter, Dodd, and Boyd perforators) of GSV. Light microscopic examination and immunohistochemistry for MMP-1, -2, -9, -13 and TIMP-1, -2 were performed.
Results: Intimal hyperplasia, fragmentation and loss of elastic fibers, infiltration of collagen fibers, and disorganization of medial muscle layers were evident in most vein samples. The degree of vein wall degeneration was not different between the 2 groups, and the anatomical sites of GSV. By immunohistochemistry, the expression of MMPs and TIMPs was not significantly different according to the group and the site. The expression of MMP-9 was more intense than that of other MMPs and TIMPs in all samples. MMP-9 was well localized to endothelial cells, medial muscle layers, and adventitial vasa vasorum.
Conclusion: There are no distinct differences in the varicose vein samples after short-term postural blood stasis compared to the resting group. MMP-9 may be the key enzyme of the venous wall remodeling.
Methods: Forty-nine vein samples were obtained from 10 patients with VVs (control group), and 34 samples from 7 VV patients after 1-hour hydrostatic stress just before surgery (stress group) at each anatomical site (proximal, Hunter, Dodd, and Boyd perforators) of GSV. Light microscopic examination and immunohistochemistry for MMP-1, -2, -9, -13 and TIMP-1, -2 were performed.
Results: Intimal hyperplasia, fragmentation and loss of elastic fibers, infiltration of collagen fibers, and disorganization of medial muscle layers were evident in most vein samples. The degree of vein wall degeneration was not different between the 2 groups, and the anatomical sites of GSV. By immunohistochemistry, the expression of MMPs and TIMPs was not significantly different according to the group and the site. The expression of MMP-9 was more intense than that of other MMPs and TIMPs in all samples. MMP-9 was well localized to endothelial cells, medial muscle layers, and adventitial vasa vasorum.
Conclusion: There are no distinct differences in the varicose vein samples after short-term postural blood stasis compared to the resting group. MMP-9 may be the key enzyme of the venous wall remodeling.
목차
서론
방법
결과
고찰
REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Callam MJ / 1994 / Epidemiology of varicose veins / Br J Surg 81 : 167 ~ 173
2. [학술지(정기간행물)] - Evans CJ / 1999 / Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study / J Epidemiol Community Health 53 : 149 ~ 153
3. [학술지(정기간행물)] - Pascarella L / 2005 / Causes of telengiectasias, reticular veins, and varicose veins / Semin Vasc Surg 18 : 2 ~ 4
4. [학술지(정기간행물)] - Naoum JJ / 2007 / Current advances in the pathogenesis of varicose veins / J Surg Res 141 : 311 ~ 316
5. [학술지(정기간행물)] - Lehoux S / 2006 / Molecular mechanisms of the vascular responses to haemodynamic forces / J Intern Med 259 : 381 ~ 392
2. [학술지(정기간행물)] - Evans CJ / 1999 / Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study / J Epidemiol Community Health 53 : 149 ~ 153
3. [학술지(정기간행물)] - Pascarella L / 2005 / Causes of telengiectasias, reticular veins, and varicose veins / Semin Vasc Surg 18 : 2 ~ 4
4. [학술지(정기간행물)] - Naoum JJ / 2007 / Current advances in the pathogenesis of varicose veins / J Surg Res 141 : 311 ~ 316
5. [학술지(정기간행물)] - Lehoux S / 2006 / Molecular mechanisms of the vascular responses to haemodynamic forces / J Intern Med 259 : 381 ~ 392
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UCI(KEPA) : I410-ECN-0101-2013-514-002681018