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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.7
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- 1 - 7 (7page)
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Purpose: A cutaneous wound healing requires a well-orchestrated integration of the complex biological and molecular events of cell migration and proliferation, extracellular matrix deposition, angiogenesis and remodeling. Finally, skin regeneration is the main goal. Stem cells are self-renewing multipotent progenitors with the broadest developmental potential in a given tissue at a given time. The aim of this study was to examine the role of stem cells during the wound healing process of cutaneous burn in hairless mice by using immunohistochemical stainings (nestin, cytokeratin 15 and CD31).
Methods: Each mouse received 2 burns at the dorsal area by applying a metal stick heated in boiling water. Burn wound sites were dressed with duoderm. The mice were sacrificed at 0, 2, 7, 14 and 21 days after burn. Histological findings and immunohistochemical expression for stem cell markers were observed.
Results: Nestin was expressed in the stromal cells beneath the epidermis, hair follices, dermal cysts and endothelial cells. Cytokeratin 15 was expressed in the epidermis except in basal cells. On 7 and 14 days after burn, the regenerated epidermis didn’t express cytokeratin 15. CD31 was expressed in the endothelial cells on 7 and 14 days after burn. The amount of nestin expression was the highest.
Conclusion: Our results showed that nestin may have various effects on burn wound healing. Cytokeratin 15 was expressed before burn and after burn. It is likely that other cytokeratin may stimulate epithelial regeneration. CD31 may act in vascular regeneration during burn healing.
Methods: Each mouse received 2 burns at the dorsal area by applying a metal stick heated in boiling water. Burn wound sites were dressed with duoderm. The mice were sacrificed at 0, 2, 7, 14 and 21 days after burn. Histological findings and immunohistochemical expression for stem cell markers were observed.
Results: Nestin was expressed in the stromal cells beneath the epidermis, hair follices, dermal cysts and endothelial cells. Cytokeratin 15 was expressed in the epidermis except in basal cells. On 7 and 14 days after burn, the regenerated epidermis didn’t express cytokeratin 15. CD31 was expressed in the endothelial cells on 7 and 14 days after burn. The amount of nestin expression was the highest.
Conclusion: Our results showed that nestin may have various effects on burn wound healing. Cytokeratin 15 was expressed before burn and after burn. It is likely that other cytokeratin may stimulate epithelial regeneration. CD31 may act in vascular regeneration during burn healing.
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REFERENCES
참고문헌 (12)
참고문헌 신청
1. [학술지(정기간행물)] - Zhu H / 2008 / Effects of nitric oxide on skin burn wound healing / J Burn Care Res 29 : 804 ~ 814
2. [학술지(정기간행물)] - Benavides F / 2009 / The hairless mouse in skin research / J Dermatol Sci 53 : 10 ~ 18
3. [학술지(정기간행물)] - Li L / 2003 / Nestin expression in hair follicle sheath progenitor cells / Proc Natl Acad Sci U S A 100 : 9958 ~ 9961
4. [학술지(정기간행물)] - Morris RJ / 2004 / Capturing and profiling adult hair follicle stem cells / Nat Biotechnol 22 : 411 ~ 417
5. [학술지(정기간행물)] - Amoh Y / 2004 / Nascent blood vessels in the skin arise from nestin-expressing hair-follicle cells / Proc Natl Acad Sci U S A 101 : 13291 ~ 13295
2. [학술지(정기간행물)] - Benavides F / 2009 / The hairless mouse in skin research / J Dermatol Sci 53 : 10 ~ 18
3. [학술지(정기간행물)] - Li L / 2003 / Nestin expression in hair follicle sheath progenitor cells / Proc Natl Acad Sci U S A 100 : 9958 ~ 9961
4. [학술지(정기간행물)] - Morris RJ / 2004 / Capturing and profiling adult hair follicle stem cells / Nat Biotechnol 22 : 411 ~ 417
5. [학술지(정기간행물)] - Amoh Y / 2004 / Nascent blood vessels in the skin arise from nestin-expressing hair-follicle cells / Proc Natl Acad Sci U S A 101 : 13291 ~ 13295
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