지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.10
- 수록면
- 240 - 244 (5page)
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초록· 키워드
오류제보하기
Purpose: The most important prognostic factor in patients with operable breast cancer is lymph node involvement. The 6th edition of AJCC categorizes metastasis to more than 10 nodes as N3, or stage IIIc. Such patients have a high risk of recurrence and death. The purpose of this study was to evaluate the prognosis of these N3 patients.
Methods: Between 1991 and 2004, 141 patients with 10 or more positive lymph nodes were treated at our institution, and we retrospectively reviewed their medical records. We analyzed patient age, tumor size, number of metastatic lymph nodes, hormone receptor status, C-erb-B2 status, and treatment modality. Survival was calculated using the Kaplan-Meier method on SPSS 12.0 software.
Results: The median follow-up duration was 55.0 months (range 3∼182 months); 78 patients had recurrence, and 44 patients died. The 5-year disease-free survival and 5-year overall survival rates were 49.4% and 64.6%, respectively. The only prognostic factor for disease-free survival was tumor size. In patients with tumors less than 2 cm in size, the 5-year disease-free survival was 68.9%, while the 5-year disease-free survival was 27.7% in patients with tumors larger than 5 cm. Hormonal receptor status, C-erb-B2 status, number of metastatic lymph nodes, and treatment modality were statistically insignificant in predicting disease-free survival. None of these factors was significant for predicting overall survival, either.
Conclusion: The 5-year disease-free survival rate was 49.4%, and it was influenced only by tumor size. Adjuvant chemotherapy and adjuvant radiotherapy were not independent factors predicting survival. Early breast tumor detection is important in N3 breast cancer patients.
Methods: Between 1991 and 2004, 141 patients with 10 or more positive lymph nodes were treated at our institution, and we retrospectively reviewed their medical records. We analyzed patient age, tumor size, number of metastatic lymph nodes, hormone receptor status, C-erb-B2 status, and treatment modality. Survival was calculated using the Kaplan-Meier method on SPSS 12.0 software.
Results: The median follow-up duration was 55.0 months (range 3∼182 months); 78 patients had recurrence, and 44 patients died. The 5-year disease-free survival and 5-year overall survival rates were 49.4% and 64.6%, respectively. The only prognostic factor for disease-free survival was tumor size. In patients with tumors less than 2 cm in size, the 5-year disease-free survival was 68.9%, while the 5-year disease-free survival was 27.7% in patients with tumors larger than 5 cm. Hormonal receptor status, C-erb-B2 status, number of metastatic lymph nodes, and treatment modality were statistically insignificant in predicting disease-free survival. None of these factors was significant for predicting overall survival, either.
Conclusion: The 5-year disease-free survival rate was 49.4%, and it was influenced only by tumor size. Adjuvant chemotherapy and adjuvant radiotherapy were not independent factors predicting survival. Early breast tumor detection is important in N3 breast cancer patients.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Ahn SH / 2006 / The Korean Breast Cancer Society. Chronological changes of clinical chanracteristics in 31,115 new breast cancer patients among Koreans during 1996∼2004 / Breast Cancer Res Treat 99 : 209 ~ 214
2. [학술지(정기간행물)] - Ahn SH / 2006 / Survival analysis of Korea beast cancer patietns. 2006 Annual Meeting of Korean Breast Cancer Society / Korean J Breast Cancer 9 (1) : 82 ~ 90
3. [학술지(정기간행물)] - Son BH / 2006 / The recurrence rate, risk factors and recurrence patterns after surgery in 3,700 patients with operable breast cancer / Korean J Breast Cancer 9 : 134 ~ 144
4. [학술지(정기간행물)] - 강선희 / 2004 / 유방암 989예의 생존율 및 예후인자 / 대한외과학회지 66 (06) : 454 ~ 461
5. [단행본] - Greene FL / 2002 / AJCC Cancer Staging Handbook from the AJCC Cancer Staging Manual. 6th ed / Springer
2. [학술지(정기간행물)] - Ahn SH / 2006 / Survival analysis of Korea beast cancer patietns. 2006 Annual Meeting of Korean Breast Cancer Society / Korean J Breast Cancer 9 (1) : 82 ~ 90
3. [학술지(정기간행물)] - Son BH / 2006 / The recurrence rate, risk factors and recurrence patterns after surgery in 3,700 patients with operable breast cancer / Korean J Breast Cancer 9 : 134 ~ 144
4. [학술지(정기간행물)] - 강선희 / 2004 / 유방암 989예의 생존율 및 예후인자 / 대한외과학회지 66 (06) : 454 ~ 461
5. [단행본] - Greene FL / 2002 / AJCC Cancer Staging Handbook from the AJCC Cancer Staging Manual. 6th ed / Springer
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UCI(KEPA) : I410-ECN-0101-2013-514-002689665