지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.9
- 수록면
- 210 - 215 (6page)
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이 논문의 연구 히스토리 (6)
2006
2004
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Purpose: Although significant advances in survival have been achieved with administering adjuvant treatments in patients with early breast carcinoma, patients with recurrent breast carcinoma usually die of their disease. There have been only a few reports on the prognostic factors of patients with recurrent disease.
Methods: Two hundred thirty nine patients were treated by this institute from 1987 to 2002. We excluded those patients who had distant metastasis within three months of primary surgery. Recurrences were diagnosed by the physical findings, image study and/or tissue biopsy. The analyzed parameters were age, the primary tumor size, the nodal status, the TNM stage, the operation method, the estrogen receptor status, the disease free interval and the site of recurrence. The univariate survival distributions were estimated by using the method of Kaplan and Meier and they were compared by using the log rank test. The potential prognostic factors were analyzed via multivariate analysis with using Cox’s proportional hazard model.
Results: The median survival time from first relapse was 19.2 months and the 2 year survival rate from recurrence was 55.7%. Univariate analysis showed that patients with negative nodal involvement, an early disease stage, positivity for estrogen receptor, a long disease free interval and nonvisceral site recurrence had significantly longer survival than the counterpart patients. Multivariate analysis showed that these factors were all independent factors with a similar relative risk, about 2.01 to 2.54.
Conclusion: Thought the number of patients included in this study is relative small, our data clearly show that an axillary lymph node status, stage, estrogen receptor positivity, a disease free interval and the metastatic site are closely associated with survival from the first recurrence.
Methods: Two hundred thirty nine patients were treated by this institute from 1987 to 2002. We excluded those patients who had distant metastasis within three months of primary surgery. Recurrences were diagnosed by the physical findings, image study and/or tissue biopsy. The analyzed parameters were age, the primary tumor size, the nodal status, the TNM stage, the operation method, the estrogen receptor status, the disease free interval and the site of recurrence. The univariate survival distributions were estimated by using the method of Kaplan and Meier and they were compared by using the log rank test. The potential prognostic factors were analyzed via multivariate analysis with using Cox’s proportional hazard model.
Results: The median survival time from first relapse was 19.2 months and the 2 year survival rate from recurrence was 55.7%. Univariate analysis showed that patients with negative nodal involvement, an early disease stage, positivity for estrogen receptor, a long disease free interval and nonvisceral site recurrence had significantly longer survival than the counterpart patients. Multivariate analysis showed that these factors were all independent factors with a similar relative risk, about 2.01 to 2.54.
Conclusion: Thought the number of patients included in this study is relative small, our data clearly show that an axillary lymph node status, stage, estrogen receptor positivity, a disease free interval and the metastatic site are closely associated with survival from the first recurrence.
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고찰
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REFERENCES
참고문헌 (21)
참고문헌 신청
1. [단행본] - Lee KM / 2005 / Natural history of breast cancer, In The Korean Breast Cancer Society. The Breast. 2nd ed / Ilchokak : 342 ~ 356
2. [학술지(정기간행물)] - Early Breast Cancer Trialists’ Collaborative Group / 2005 / Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival:an overview of the randomized trials / Lancet 365 : 1687 ~ 1717
3. [보고서] - Ministry of Health and Welfare, Republic of Korea / 2002 / Annual Report of the Central Cancer Registry in Korea (2000.1.∼2000.12.)
4. [단행본] - Wood WC / 2005 / Malignant tumors of the breast, In Cancer. Principles and Practice of Oncology. 7th ed / Lippincott Williams and Wilkins : 1415 ~ 1471
5. [학술지(정기간행물)] - Insa A / 1999 / Prognostic factors predicting survival from first recurrence in patients with metastatic breast cancer: analysis of 439 patients / Breast Cancer Res Treat 56 : 67 ~ 78
2. [학술지(정기간행물)] - Early Breast Cancer Trialists’ Collaborative Group / 2005 / Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival:an overview of the randomized trials / Lancet 365 : 1687 ~ 1717
3. [보고서] - Ministry of Health and Welfare, Republic of Korea / 2002 / Annual Report of the Central Cancer Registry in Korea (2000.1.∼2000.12.)
4. [단행본] - Wood WC / 2005 / Malignant tumors of the breast, In Cancer. Principles and Practice of Oncology. 7th ed / Lippincott Williams and Wilkins : 1415 ~ 1471
5. [학술지(정기간행물)] - Insa A / 1999 / Prognostic factors predicting survival from first recurrence in patients with metastatic breast cancer: analysis of 439 patients / Breast Cancer Res Treat 56 : 67 ~ 78
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UCI(KEPA) : I410-ECN-0101-2013-514-002673094