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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 199 - 206 (8page)
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Purpose: We examined the clinical significance of MUC2 and MUC5AC gene expression in gastric adeno-carcinoma tissues.
Methods: Two hundred specimens were obtained from gastric carcinoma patients who underwent gastric cancer operations at Samsung Medical Center between January 2001 and January 2005. MUC2 and MUC5AC expression were examined immunohistochemically, and correlated with clinicopathologic features and prognostic significance.
Results: MUC2 expression was positive in 88 tissues (44.0%) and MUC5AC expression was positive in 125 tissues (62.5%). MUC2 expression was associated with cancer advancement, lymph node metastasis, T classification, distant metastasis, and endolymphatic invasion. Loss of MUC5AC expression was significantly related to cancer advancement, lymph node metastasis, advanced T stage, and distant metastasis. MUC2 expression was usually negative in early gastric cancer (78%), but usually positive in advanced gastric cancer (66%). MUC5AC was usually positive in early gastric cancer (74%). The prognosis of the MUC2(-) group was significantly better than the MUC2(+) group (P＜0.001). There was no relationship with MUC5AC expression and survival. Multivariate analysis showed that T classification, lymph node metastasis, distant metastasis, endolymphatic invasion, and MUC2 expression were independent prognostic factors, but MUC5AC expression was not.
Conclusion: MUC2 and MUC5AC expression correlated with several clinicopathologic parameters (cancer advancement, lymph node metastasis, advanced T classification, distant metastasis). MUC2 expression was a significant independent prognostic factor and positive MUC2 expression suggested poor prognosis. MUC2 expression may have prognostic significance in gastric adeno-carcinomas.
Methods: Two hundred specimens were obtained from gastric carcinoma patients who underwent gastric cancer operations at Samsung Medical Center between January 2001 and January 2005. MUC2 and MUC5AC expression were examined immunohistochemically, and correlated with clinicopathologic features and prognostic significance.
Results: MUC2 expression was positive in 88 tissues (44.0%) and MUC5AC expression was positive in 125 tissues (62.5%). MUC2 expression was associated with cancer advancement, lymph node metastasis, T classification, distant metastasis, and endolymphatic invasion. Loss of MUC5AC expression was significantly related to cancer advancement, lymph node metastasis, advanced T stage, and distant metastasis. MUC2 expression was usually negative in early gastric cancer (78%), but usually positive in advanced gastric cancer (66%). MUC5AC was usually positive in early gastric cancer (74%). The prognosis of the MUC2(-) group was significantly better than the MUC2(+) group (P＜0.001). There was no relationship with MUC5AC expression and survival. Multivariate analysis showed that T classification, lymph node metastasis, distant metastasis, endolymphatic invasion, and MUC2 expression were independent prognostic factors, but MUC5AC expression was not.
Conclusion: MUC2 and MUC5AC expression correlated with several clinicopathologic parameters (cancer advancement, lymph node metastasis, advanced T classification, distant metastasis). MUC2 expression was a significant independent prognostic factor and positive MUC2 expression suggested poor prognosis. MUC2 expression may have prognostic significance in gastric adeno-carcinomas.
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REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Ho SB / 1995 / Mucin gene expression in normal, preneoplastic and neoplastic human gastric epithelium / Cancer Res 55 : 2681 ~ 2690
2. [학술지(정기간행물)] - Kocer B / 2004 / Prognostic significance of mucin expression in gastric carcinoma / Dig Dis Sci 49 : 954 ~ 964
3. [학술지(정기간행물)] - Reis CA / 2000 / Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas / J Histochem Cytochem 48 : 377 ~ 388
4. [학술지(정기간행물)] - Byrd JC / 2004 / Mucins and mucin binding proteins in colorectal cancer / Cancer Metastasis Rev 23 : 77 ~ 99
5. [학술지(정기간행물)] - Ho SB / 2004 / The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteins / Dig Dis Sci 49 : 1598 ~ 1606
2. [학술지(정기간행물)] - Kocer B / 2004 / Prognostic significance of mucin expression in gastric carcinoma / Dig Dis Sci 49 : 954 ~ 964
3. [학술지(정기간행물)] - Reis CA / 2000 / Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas / J Histochem Cytochem 48 : 377 ~ 388
4. [학술지(정기간행물)] - Byrd JC / 2004 / Mucins and mucin binding proteins in colorectal cancer / Cancer Metastasis Rev 23 : 77 ~ 99
5. [학술지(정기간행물)] - Ho SB / 2004 / The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteins / Dig Dis Sci 49 : 1598 ~ 1606
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UCI(KEPA) : I410-ECN-0101-2013-514-002693489