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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 552 - 557 (6page)
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Background and Objectives Multi-walled carbon nanotubes (MWCNT) are one of the most commonly used nanomaterials to date. Recent studies have demonstrated that MWCNT increase immune response and allergic inflammation in airway epithelial cells. However, the effects of MWCNT on mucin in human airway epithelial cells have not been reported. Therefore, in the present study, the effect of MWCNT on MUC16, MUC5AC, and MUC5B expressions were investigated in human airway epithelial cells.
Subjects and Method In mucin-producing human NCI-H292 airway epithelial cells and primary cultures of normal nasal epithelial cells, the effects of MWCNT on MUC16, MUC5AC, and MUC5B expression were analyzed by reverse transcription polymerase chain reaction, real-time polymerase chain reaction, and enzyme-linked immunosorbent assay.
Results In human NCI-H292 airway epithelial cells, MWCNT significantly induced the expression MUC5AC and MUC5B mRNA and the production of MUC5AC and MUC5B protein. However, MWCNT did not induce the expression of MUC16 mRNA. In the primary cultures of normal nasal epithelial cells, MWCNT also induced the expression of MUC5AC and MUC5B mRNA and the production of MUC5AC and MUC5B proteins.
Conclusion The results of this study demonstrate that MWCNT induces MUC5AC and MUC5B expression in human airway epithelial cells. These findings provide important information about the biological role of MWCNT on mucus-secretion in human airway epithelial cells.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Aillon KL / 2009 / Effects of nanomaterial physicochemical properties on in vivo toxicity / Adv Drug Deliv Rev 61 (6) : 457 ~ 466
Ajayan PM / 1999 / Nanotubes from Carbon / Chem Rev 99 (7) : 1787 ~ 1800
Ali MS / 2007 / Upper airway mucin gene expression: a review / Laryngoscope 117 (5) : 932 ~ 938
Andrews R / 2002 / Multiwall carbon nanotubes:synthesis and application / Acc Chem Res 35 (12) : 1008 ~ 1017
Bae CH / 2012 / Diallyl disulfide induces MUC5B expression via ERK2 in human airway epithelial cells / Phytother Res 26 (2) : 197 ~ 203
Ajayan PM / 1999 / Nanotubes from Carbon / Chem Rev 99 (7) : 1787 ~ 1800
Ali MS / 2007 / Upper airway mucin gene expression: a review / Laryngoscope 117 (5) : 932 ~ 938
Andrews R / 2002 / Multiwall carbon nanotubes:synthesis and application / Acc Chem Res 35 (12) : 1008 ~ 1017
Bae CH / 2012 / Diallyl disulfide induces MUC5B expression via ERK2 in human airway epithelial cells / Phytother Res 26 (2) : 197 ~ 203
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